327081-00-5
327081-00-5
Chemical Structure
SMAPP1
- CAS No.: 327081-00-5
- Formula:C27H25N5O5S2
- Molecular Weight:563.65
IUPAC Name: N-(4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
InChIKey: NSPZPPYCIWIANY-UHFFFAOYSA-N
SMILES: O=C(C1N(S(=O)(C2=CC=C(C)C=C2)=O)CC3=C(C=CC=C3)C1)NC4=CC=C(S(=O)(NC5=NC=CC=N5)=O)C=C4
Biological Activity: SMAPP1 is an activator of protein phosphatase-1 (PP1). SMAPP1 increases phosphorylation of CDK9’s Ser90 and Thr186 residues, but not Ser175. SMAPP1 induces HIV-1 replication, upregulates HIV-1 transcription that led to the reactivation of latent HIV-1 provirus[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SMAPP1 | 99.43% | SMAPP1 is an activator of protein phosphatase-1 (PP1). SMAPP1 increases phosphorylation of CDK9’s Ser90 and Thr186 residues, but not Ser175. SMAPP1 induces HIV-1 replication, upregulates HIV-1 transcription that led to the reactivation of latent HIV-1 provirus. | ||||||||||||||||||||
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