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Cat. No.: HY-162557

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VEGFR-2-IN-45

VEGFR-2-IN-45 (compound 3j) is a potent inhibitor of VEGFR-2, with the IC₅₀ of 0.2 μM. VEGFR-2-IN-45 plays an important role in cancer research.

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CAS No.: 3042018-08-3
Formule: C₂₈H₂₃ClN₆O₃S
Masse moléculaire:559.04

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

VEGFR-2-IN-45 Chemical Structure

CAS No.: 3042018-08-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

VEGFR-2-IN-45 (compound 3j) is a potent inhibitor of VEGFR-2, with the IC₅₀ of 0.2 μM. VEGFR-2-IN-45 plays an important role in cancer research^[1].

IC₅₀ & Target

VEGFR-2

0.2 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform VEGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7.66 μM Compound: 3j	Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 38894896]
HUVEC	IC₅₀	178.7 μM Compound: 3j	Cytotoxicity against HUVECs incubated for 72 hrs by MTT assay Cytotoxicity against HUVECs incubated for 72 hrs by MTT assay	[PMID: 38894896]
MCF7	IC₅₀	5.86 μM Compound: 3j	Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 38894896]
WI-38	IC₅₀	21.63 μM Compound: 3j	Cytotoxicity against human WI-38 cells incubated for 72 hrs by MTT assay Cytotoxicity against human WI-38 cells incubated for 72 hrs by MTT assay	[PMID: 38894896]

Chemical Information

CAS No. 3042018-08-3
Masse moléculaire 559.04
Formule C₂₈H₂₃ClN₆O₃S
SMILES

O=C(N1C2=CC=C(S(=O)(NC3=NC=CC=N3)=O)C=C2)/C(N=C1C4=CC=C(Cl)C=C4)=C/C5=CC=C(N(C)C)C=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Manar R, et al. Insight on Some Newly Synthesized Trisubstituted Imidazolinones as VEGFR-2 Inhibitors. ACS Med. Chem. Lett. MAY 20, 2024.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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VEGFR-2-IN-45

Voir tous les produits spécifiques à Isoform VEGFR

Activité biologique

Description

IC50 & Target

Cellular Effect

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VEGFR-2-IN-45 Related Classifications

HY-162557 Related Classifications

Bioz

Keywords

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