VEGFR-2-IN-45
VEGFR-2-IN-45 (compound 3j) is a potent inhibitor of VEGFR-2, with the IC50 of 0.2 μM. VEGFR-2-IN-45 plays an important role in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3042018-08-3
- Formula: C28H23ClN6O3S
- Molecular Weight:559.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All VEGFR Isoforms
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Biological Activity
|
VEGFR-2 0.2 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
7.66 μM
Compound: 3j
|
Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
|
[PMID: 38894896] |
| HUVEC | IC50 |
178.7 μM
Compound: 3j
|
Cytotoxicity against HUVECs incubated for 72 hrs by MTT assay
Cytotoxicity against HUVECs incubated for 72 hrs by MTT assay
|
[PMID: 38894896] |
| MCF7 | IC50 |
5.86 μM
Compound: 3j
|
Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay
|
[PMID: 38894896] |
| WI-38 | IC50 |
21.63 μM
Compound: 3j
|
Cytotoxicity against human WI-38 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human WI-38 cells incubated for 72 hrs by MTT assay
|
[PMID: 38894896] |
Chemical Information
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CAS No. 3042018-08-3
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Molecular Weight 559.04
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Formula C28H23ClN6O3S
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SMILES
O=C(N1C2=CC=C(S(=O)(NC3=NC=CC=N3)=O)C=C2)/C(N=C1C4=CC=C(Cl)C=C4)=C/C5=CC=C(N(C)C)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)