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  3. BRD-K98645985

BRD-K98645985 

Cat. No.: HY-114268
Handling Instructions

BRD-K98645985 is a class of 12-membered macrolactam and a BAF (Brg/Brahma-associated factors) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, and without T cell activation or toxicity.

For research use only. We do not sell to patients.

BRD-K98645985 Chemical Structure

BRD-K98645985 Chemical Structure

CAS No. : 1357647-78-9

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1 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
5 mg USD 6500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

BRD-K98645985 is a class of 12-membered macrolactam and a BAF (Brg/Brahma-associated factors) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, and without T cell activation or toxicity[1].

IC50 & Target[1]

BAF transcriptional repression

2.37 μM (EC50)

HIV-1

 

In Vitro

BRD-K98645985 (30 µM; 18 hours) treatment shows a 5-fold increase in Bmi1, 2.6-fold increase in Ring1, and 3.3-fold decrease in Fgf4[1].
BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting[1].

Molecular Weight

573.73

Formula

C₃₃H₄₃N₅O₄

CAS No.

1357647-78-9

SMILES

O=C(NC1=CC=C(OC[[email protected]](C)N(CC2=CC=C(C3=NC=CC=C3)C=C2)C[[email protected]](C)[[email protected]@H](OC)CN(C)C4=O)C4=C1)NC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BRD-K98645985HIVHuman immunodeficiency virusBAFARID1Anon-toxic12-memberedmacrolactamlatencyreversalGFPT-cellsviralInhibitorinhibitorinhibit

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Product name:
BRD-K98645985
Cat. No.:
HY-114268
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