2109805-83-4
2109805-83-4
Chemical Structure
UMB-136
- CAS No.: 2109805-83-4
- Formula:C24H27N5O2
- Molecular Weight:417.50
IUPAC Name: N-cyclohexyl-2-(4-(3,5-dimethylisoxazol-4-yl)-2-methoxyphenyl)imidazo[1,2-a]pyrazin-3-amine
InChIKey: JEWZSWPGZVIJJN-UHFFFAOYSA-N
SMILES: COC1=CC(C2=C(ON=C2C)C)=CC=C1C3=C(N4C(C=NC=C4)=N3)NC5CCCCC5
Biological Activity: UMB-136 is a bromodomain inhibitor. UMB-136 is a promising latency-reversing agent (LRA) for HIV-1 eradication. UMB-136 reactivates HIV-1 in multiple cell models. UMB-136 enhances HIV-1 transcription and increases viral production through the release of P-TEFb[1].
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UMB-136 | UMB-136 is a bromodomain inhibitor. UMB-136 is a promising latency-reversing agent (LRA) for HIV-1 eradication. UMB-136 reactivates HIV-1 in multiple cell models. UMB-136 enhances HIV-1 transcription and increases viral production through the release of P-TEFb. | |||||||||||||||||||||
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References
Keywords
