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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
Haspin
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "Haspin" in MCE Product Catalog:
13
13 Publications Verification
Synonyms: NSC 113939; 5-ITu
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5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .
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8 Cited Publications
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CHR-6494 is a potent inhibitor of haspin, with an IC50 of 2 nM. CHR-6494 inhibits histone H3T3 phosphorylation. CHR-6494 can be used in the research of cancer .
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MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells .
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2 Cited Publications
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LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively .
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2 Cited Publications
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LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively .
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LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with180-fold selectivity verses DYRK2 (IC50=9.9 μM). LDN-209929 is a optimized analogue of LDN-192960 (HY-13455) .
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Haspin-IN-3 (compound 8l) is a potent haspin inhibitor with IC50 of 14 nM. Haspin-IN-3 has anticancer effects .
Cat. No.: HY-163858
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Haspin-IN-4 (Compound 60) is a selective inhibitor of Haspin with an IC50 value of 0.01 nM. Haspin-IN-4 possesses anticancer activity and can be used in cancer research .
Cat. No.: HY-146586
CAS No.: 2768474-30-0
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Haspin-IN-1 (compound 2a) is a haspin inhibitor with an IC50 of 119 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 221 nM and 916.3 nM, respectively .
Cat. No.: HY-15424R
CAS No.: 24386-93-4
Synonyms: NSC 113939 (Standard); 5-ITu (Standard)
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5-Iodotubercidin (Standard) is the analytical standard of 5-Iodotubercidin. This product is intended for research and analytical applications. 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .
Cat. No.: HY-155341
CAS No.: 3022263-37-9
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HSK205 is a dual FLT3 and haspin inhibitor, with IC50 of 0.187 nM for FLT3. HSK205 has antitumor activity .
Cat. No.: HY-170546
CAS No.: 3067968-52-6
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MU1920 is an ATP-competitive, selective inhibitor for haspin with an IC50 of 6 nM. MU1920 exhibits good pharmacokinetic properties and metabolic stability in mouse plasma and microsomes without obvious anticancer effects, which can be used for development of chemical probes .
Cat. No.: HY-146587
CAS No.: 2768474-47-9
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Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC50 of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 445 nM and 917 nM, respectively .
Cat. No.: HY-110350
CAS No.: 1458630-17-5
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CHR-6494 TFA is a potent inhibitor of haspin, with an IC50 of 2 nM. CHR-6494 TFA inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be used in the research of cancer .
Cat. No.: HY-135002
CAS No.: 1233355-57-1
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LDN-209929 is a potent haspin kinase inhibitor, with IC50 values of 55 nM and 9.9 μM for Haspin and DYRK2, respectively .
Cat. No.: HY-RS06009
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HASPIN Human Pre-designed siRNA Set A contains three designed siRNAs for HASPIN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06010
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Haspin Mouse Pre-designed siRNA Set A contains three designed siRNAs for Haspin gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06011
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Haspin Rat Pre-designed siRNA Set A contains three designed siRNAs for Haspin gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-112366
CAS No.: 896138-40-2
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FLT3-IN-38 (Flt-3 Inhibitor II) is a FLT3 inhibitor. FLT3-IN-38 has off-target effects and inhibits serine/threonine kinase haspin. Haspin is a mitotic signal coordinator. FLT3-IN-38 can be used for cancer research .
Cat. No.: HY-179486
CAS No.: 2878446-03-6
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Anticancer agent 285 is an orally active anticancer agent with highly effective and selective haspin-inhibiting IC50 = 18 nM) activity. Anticancer agent 285 can be used for the study of colorectal cancer[1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
