Haspin-IN-4
Haspin-IN-4 (Compound 60) is a selective inhibitor of Haspin with an IC50 value of 0.01 nM. Haspin-IN-4 possesses anticancer activity and can be used in cancer research.
For research use only. We do not sell to patients.
- Formula: C25H33N5O
- Molecular Weight:419.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 0.01 nM (Haspin)[1].
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | EC50 |
24.31 μM
Compound: 60
|
Cytotoxicity against human A-375 cells incubated for 48 to 72 hrs by MTT assay
Cytotoxicity against human A-375 cells incubated for 48 to 72 hrs by MTT assay
|
[PMID: 39038808] |
| HeLa | EC50 |
7.78 μM
Compound: 60
|
Cytotoxicity against human HeLa cells incubated for 48 to 72 hrs by MTT assay
Cytotoxicity against human HeLa cells incubated for 48 to 72 hrs by MTT assay
|
[PMID: 39038808] |
| IEC-6 | EC50 |
>40 μM
Compound: 60
|
Cytotoxicity against rat IEC-6 cells incubated for 48 to 72 hrs by MTT assay
Cytotoxicity against rat IEC-6 cells incubated for 48 to 72 hrs by MTT assay
|
[PMID: 39038808] |
| MCF7 | EC50 |
15.81 μM
Compound: 60
|
Cytotoxicity against human MCF7 cells incubated for 48 to 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells incubated for 48 to 72 hrs by MTT assay
|
[PMID: 39038808] |
| MIA PaCa-2 | EC50 |
16.43 μM
Compound: 60
|
Cytotoxicity against human MIA PaCa-2 cells incubated for 48 to 72 hrs by MTT assay
Cytotoxicity against human MIA PaCa-2 cells incubated for 48 to 72 hrs by MTT assay
|
[PMID: 39038808] |
| Raji | EC50 |
18.82 μM
Compound: 60
|
Cytotoxicity against human Raji cells incubated for 48 to 72 hrs by MTT assay
Cytotoxicity against human Raji cells incubated for 48 to 72 hrs by MTT assay
|
[PMID: 39038808] |
Chemical Information
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Molecular Weight 419.56
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Formula C25H33N5O
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SMILES
CN1C=C(C2=CC(C(NC3=CC=C(C(C)=C3)C)=O)=CC=C21)CNCCN4CCNCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)