HSK205
Based on 1 Customer Validation
HSK205 is a dual FLT3 and haspin inhibitor, with IC50 of 0.187 nM for FLT3. HSK205 has antitumor activity.
For research use only. We do not sell to patients.
- Purity : 98.01%
- CAS No.: 3022263-37-9
- Formula: C26H24N6O
- Molecular Weight:436.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-14 | GI50 |
2.2 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells expressing FLT3 F691L mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells expressing FLT3 F691L mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MOLM-14 | GI50 |
22.4 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MOLM-14 | GI50 |
4.3 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells expressing FLT3 D835Y mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells expressing FLT3 D835Y mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MV4-11 | GI50 |
8.9 nM
Compound: 14; HSK205
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Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
Chemical Information
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CAS No. 3022263-37-9
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Appearance Solid
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Molecular Weight 436.51
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Formula C26H24N6O
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Color Off-white to light yellow
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SMILES
O=C(NCC1=NC(C)=CN1)C(C=C2)=CC=C2C(C3=C4CCCC3)=NC5=C4C(C=NN6)=C6C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 4.17 mg/mL (9.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2909 mL | 11.4545 mL | 22.9090 mL | 57.2725 mL |
| 5 mM | 0.4582 mL | 2.2909 mL | 4.5818 mL | 11.4545 mL |
HSK205 Related Classifications
HY-155341 Related Classifications
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