2. Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage
  3. FLT3 Haspin Kinase
  4. HSK205

HSK205 is a dual FLT3 and haspin inhibitor, with IC50 of 0.187 nM for FLT3. HSK205 has antitumor activity.

For research use only. We do not sell to patients.

HSK205

HSK205 Chemical Structure

CAS No. : 3022263-37-9

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Based on 1 publication(s) in Google Scholar

HSK205 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

HSK205 is a dual FLT3 and haspin inhibitor, with IC50 of 0.187 nM for FLT3. HSK205 has antitumor activity[1].

Cellular Effect
Cell Line Type Value Description References
MOLM-14 GI50
2.2 nM
Compound: 14; HSK205
Anticancer activity against human MOLM-14 cells expressing FLT3 F691L mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells expressing FLT3 F691L mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
[PMID: 37731695]
MOLM-14 GI50
22.4 nM
Compound: 14; HSK205
Anticancer activity against human MOLM-14 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
[PMID: 37731695]
MOLM-14 GI50
4.3 nM
Compound: 14; HSK205
Anticancer activity against human MOLM-14 cells expressing FLT3 D835Y mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells expressing FLT3 D835Y mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
[PMID: 37731695]
MV4-11 GI50
8.9 nM
Compound: 14; HSK205
Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
[PMID: 37731695]
Molecular Weight

436.51

Formula

C26H24N6O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCC1=NC(C)=CN1)C(C=C2)=CC=C2C(C3=C4CCCC3)=NC5=C4C(C=NN6)=C6C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (9.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2909 mL 11.4545 mL 22.9090 mL
5 mM 0.4582 mL 2.2909 mL 4.5818 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2909 mL 11.4545 mL 22.9090 mL 57.2725 mL
5 mM 0.4582 mL 2.2909 mL 4.5818 mL 11.4545 mL
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HSK205 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSK2053022263-37-9HSK 205HSK-205FLT3Haspin KinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3FLT3/Haspin InhibitorCancerInhibitorinhibitorinhibit

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