HSK205
Based on 1 Customer Validation
HSK205 is a dual FLT3 and haspin inhibitor, with IC50 of 0.187 nM for FLT3. HSK205 has antitumor activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.01%
- CAS 番号: 3022263-37-9
- 分子式: C26H24N6O
- 分子量:436.51
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
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Kinase Inhibitor Library
HY-L009
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Blood Cancer Compound Library
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Membrane Protein-targeted Compound Library
HY-L149
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Cytokine Inhibitors Library
HY-L161
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Serine/Threonine Kinase Inhibitor Library
HY-L164
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Anti-Hematopathy Compound Library
HY-L171
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-14 | GI50 |
2.2 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells expressing FLT3 F691L mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells expressing FLT3 F691L mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MOLM-14 | GI50 |
22.4 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MOLM-14 | GI50 |
4.3 nM
Compound: 14; HSK205
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Anticancer activity against human MOLM-14 cells expressing FLT3 D835Y mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MOLM-14 cells expressing FLT3 D835Y mutant assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
| MV4-11 | GI50 |
8.9 nM
Compound: 14; HSK205
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Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
Anticancer activity against human MV4-11 cells assessed as reduction in cell proliferation incubated for 72 hrs CellTiter-Blue Cell Viability Assay
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[PMID: 37731695] |
化学情報
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CAS 番号 3022263-37-9
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性状 Solid
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分子量 436.51
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分子式 C26H24N6O
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Color Off-white to light yellow
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SMILES
O=C(NCC1=NC(C)=CN1)C(C=C2)=CC=C2C(C3=C4CCCC3)=NC5=C4C(C=NN6)=C6C=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 4.17 mg/mL (9.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
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- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2909 mL | 11.4545 mL | 22.9090 mL | 57.2725 mL |
| 5 mM | 0.4582 mL | 2.2909 mL | 4.5818 mL | 11.4545 mL |
HSK205 関連分類
HY-155341 関連分類
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