Haspin-IN-1
Haspin-IN-1 (compound 2a) is a haspin inhibitor with an IC50 of 119 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 221 nM and 916.3 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2768474-30-0
- Formula: C12H8N4O2S
- Molecular Weight:272.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Haspin Kinase 119 nM (IC50) |
CLK1 221 nM (IC50) |
DYRK1A 916.3 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HBL-100 | EC50 |
1.3 μM
Compound: 2a
|
Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
|
[PMID: 35447555] |
| HCT-116 | EC50 |
1.1 μM
Compound: 2a
|
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
|
[PMID: 35447555] |
| SH-SY5Y | EC50 |
1.2 μM
Compound: 2a
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Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
|
[PMID: 35447555] |
| TERT-RPE1 | EC50 |
0.8 μM
Compound: 2a
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Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
|
[PMID: 35447555] |
| U2OS | EC50 |
0.9 μM
Compound: 2a
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Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
|
[PMID: 35447555] |
Chemical Information
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CAS No. 2768474-30-0
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Molecular Weight 272.28
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Formula C12H8N4O2S
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SMILES
CSC1=NC2=C(C3=C(C=C2C=N1)C=NC=C3)[N+]([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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