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製品番号: HY-146587

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Haspin-IN-2

Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC₅₀ of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC₅₀s of 445 nM and 917 nM, respectively.

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CAS 番号: 2768474-47-9
分子式: C₁₂H₈N₄O₃
分子量:256.22

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Haspin-IN-2 構造式

CAS 番号: 2768474-47-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

Haspin Kinase

50 nM (IC₅₀)

CLK1

445 nM (IC₅₀)

DYRK1A

917 nM (IC₅₀)

CDK アイソフォーム固有の製品をすべて表示 :

DYRK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HBL-100	EC₅₀	8.5 μM Compound: 4	Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 35447555]
HBL-100	EC₅₀	9.6 μM Compound: Cpd I	Antiproliferative activity against human HBL-100 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human HBL-100 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38320389]
HCT-116	EC₅₀	5.8 μM Compound: Cpd I	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38320389]
HCT-116	EC₅₀	6.2 μM Compound: 4	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 35447555]
SH-SY5Y	EC₅₀	4.3 μM Compound: Cpd I	Antiproliferative activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38320389]
SH-SY5Y	EC₅₀	4.4 μM Compound: 4	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 35447555]
TERT-RPE1	EC₅₀	3.2 μM Compound: 4	Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 35447555]
TERT-RPE1	EC₅₀	4.5 μM Compound: Cpd I	Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38320389]
U2OS	EC₅₀	5.8 μM Compound: 4	Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 35447555]
U2OS	EC₅₀	5.9 μM Compound: Cpd I	Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38320389]

化学情報

CAS 番号 2768474-47-9
分子量 256.22
分子式 C₁₂H₈N₄O₃
SMILES

COC1=NC2=C(C3=C(C=C2C=N1)C=NC=C3)[N+]([O-])=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wael Zeinyeh, et al. Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity. Eur J Med Chem. 2022 Jun 5;236:114369. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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Haspin-IN-2

CDK アイソフォーム固有の製品をすべて表示

DYRK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Haspin-IN-2 関連分類

HY-146587 関連分類