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Cat. No.: HY-146587

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Haspin-IN-2

Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC₅₀ of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC₅₀s of 445 nM and 917 nM, respectively.

For research use only. We do not sell to patients.

CAS No.: 2768474-47-9
Formula: C₁₂H₈N₄O₃
Molecular Weight:256.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Haspin-IN-2 Chemical Structure

CAS No.: 2768474-47-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Haspin Kinase

50 nM (IC₅₀)

CLK1

445 nM (IC₅₀)

DYRK1A

917 nM (IC₅₀)

All CDK Isoforms :

All DYRK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HBL-100	EC₅₀	8.5 μM Compound: 4	Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 35447555]
HBL-100	EC₅₀	9.6 μM Compound: Cpd I	Antiproliferative activity against human HBL-100 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human HBL-100 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38320389]
HCT-116	EC₅₀	5.8 μM Compound: Cpd I	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38320389]
HCT-116	EC₅₀	6.2 μM Compound: 4	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 35447555]
SH-SY5Y	EC₅₀	4.3 μM Compound: Cpd I	Antiproliferative activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38320389]
SH-SY5Y	EC₅₀	4.4 μM Compound: 4	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 35447555]
TERT-RPE1	EC₅₀	3.2 μM Compound: 4	Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 35447555]
TERT-RPE1	EC₅₀	4.5 μM Compound: Cpd I	Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38320389]
U2OS	EC₅₀	5.8 μM Compound: 4	Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay	[PMID: 35447555]
U2OS	EC₅₀	5.9 μM Compound: Cpd I	Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 38320389]

Chemical Information

CAS No. 2768474-47-9
Molecular Weight 256.22
Formula C₁₂H₈N₄O₃
SMILES

COC1=NC2=C(C3=C(C=C2C=N1)C=NC=C3)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wael Zeinyeh, et al. Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity. Eur J Med Chem. 2022 Jun 5;236:114369. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Haspin-IN-2

All CDK Isoforms

All DYRK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Haspin-IN-2 Related Classifications

HY-146587 Related Classifications