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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
K-Ras G12C-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "K-Ras G12C-IN-1" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-18604
CAS No.: 1629265-17-3
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1.
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Research Areas:
Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186). PROTAC KRAS G12C degrader-1 is a Cereblon-based KRAS G12C degrader .
Cat. No.: HY-179443
CAS No.: 3092446-09-5
SOS1-IN-25 is an SOS1 inhibitor. SOS1-IN-25 exhibits inhibitory activity against KRAS G12C/SOS1 complex formation (IC50 = 11.11 nM). SOS1-IN-25 leads to a dose-dependent decrease in pERK levels. SOS1-IN-25 can be used for the study of leukemia .
Cat. No.: HY-W142207
CAS No.: 2345-61-1
Target:
Research Areas:
(E)-3-Chloroacrylic acid is an intermediate. (E)-3-Chloroacrylic acid can be used in the synthesis of Compound 81. (E)-3-Chloroacrylic acid can be used in research on human non-small cell lung cancer with KRAS G12C mutation . (E)-3-Chloroacrylic acid is a substrate of trans-3-chloroacrylic acid dehalogenase (Km = 34 µM) .
Cat. No.: HY-175560
CAS No.: 3092445-74-1
SOS1-IN-22 is a son of sevenless homolog 1 (SOS1) inhibitor. SOS1-IN-22 can inhibit KRAS-G12C/SOS1 complex formation with an IC50 value of 40.28 nM. SOS1-IN-22 can reduce phosphorylation ERK levels. SOS1-IN-22 can be used for the research of cancer, such as pancreatic carcinoma and appendiceal carcinoma .
Cat. No.: HY-153881
CAS No.: 2768099-51-8
KRAS G12C degrader-1 (Compound 283) is a potent KRAS G12C degrader (DC50: < 100 nM) for cancer research. KRAS G12C degrader-1 is a chaperone (HSP90)-mediated protein degrader (CHAMPs) .
Cat. No.: HY-147636
CAS No.: 2508134-76-5
KRAS G12C inhibitor 55 (Compound 1) is a KRAS G12C inhibitor .
Cat. No.: HY-112494
CAS No.: 2206736-07-2
KRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.
Cat. No.: HY-159163
CAS No.: 2093328-45-9
KRASG12C IN-12 (compound-1) is a KRAS G12C inhibitor. KRASG12C IN-12 (compound-1) can form a ternary complex with intracellular CYPA and the activated KRAS G12C mutant .
Cat. No.: HY-170326
CAS No.: 1207597-54-3
Research Areas:
Hsp90-in-35 is an inhibitor of Hsp90, with an IC50 between 0.05 and 0.5 μM. HSP90-IN-35 has antitumor activity. HSP90-IN-35 can be used to synthesize KRAS G12C degrader-1 (PROTAC) (HY-153881) .
Cat. No.: HY-175244
Target:
Research Areas:
SOS1-IN-20 (Compound 12f) is an orally active SOS1 inhibitor with an IC50 of 5.11 nM against KRAS G12C::SOS1. By disrupting the interaction between KRAS and SOS1, SOS1-IN-20 inhibits KRAS activation and downstream signal transduction. SOS1-IN-20 has an IC50 of 253 nM for p-ERK in PC-9 cells and 16.71 μM for hERG channel . SOS1-IN-20 can inhibit the proliferation of tumor cells and has antitumor activity .
Cat. No.: HY-147632
CAS No.: 2762632-78-8
KRAS G12C inhibitor 51 (example 1) is a KRAS G12C inhibitor .
Cat. No.: HY-147633
CAS No.: 2761204-87-7
KRAS G12C inhibitor 52 (Compound 7) is a KRAS G12C inhibitor .
Cat. No.: HY-147634
CAS No.: 2761968-93-6
KRAS G12C inhibitor 53 (Compound 1) is a KRAS G12C inhibitor .
Cat. No.: HY-147635
CAS No.: 2765580-17-2
KRAS G12C inhibitor 54 (Compound 1) is a KRAS G12C inhibitor .
Cat. No.: HY-142947
CAS No.: 2670380-74-0
KRAS G12C inhibitor 45 (compound 78) is a potent KRAS G12C inhibitor .
Cat. No.: HY-142948
CAS No.: 2573769-23-8
KRAS G12C inhibitor 46 (compound WX003) is a potent KRAS G12C inhibitor .
Cat. No.: HY-112491
CAS No.: 2158297-28-8
KRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
