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Results for "

KCa3.1

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

3

Peptides

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18723
    Yoda 1
    Maximum Cited Publications
    100 Publications Verification

    		 Piezo Channel Akt ERK Potassium Channel Cardiovascular Disease
    Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation .
    Yoda 1
  • HY-50694
    Senicapoc
    10+ Cited Publications

    ICA-17043

    		 Potassium Channel Others
    Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca 2+-activated K + channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca 2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM .
    Senicapoc
  • HY-P4121
    L17E

    		Potassium Channel Inflammation/Immunology Cancer
    L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .
    L17E
  • HY-111655
    SKA-31
    4 Publications Verification

    		 Potassium Channel Cardiovascular Disease
    SKA-31 is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure .
    SKA-31
  • HY-15707
    NS6180
    1 Publications Verification

    		 Potassium Channel Inflammation/Immunology
    NS6180 is a new orally active KCa3.1 channel inhibitor. NS6180 inhibits cloned human KCa3.1 channels with an IC50value of 9 nM. NS6180 can be used for the research of inflammatory bowel disease (IBD) .
    NS6180
  • HY-107414
    SKA-121
    3 Publications Verification

    		 Potassium Channel Cardiovascular Disease
    SKA-121 is a selective KCa3.1 activator. SKA-121 exhibits EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively.
    SKA-121
  • HY-100418
    SKA-111
    1 Publications Verification

    		 Potassium Channel Cardiovascular Disease
    SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research .
    SKA-111
  • HY-103308
    TRAM-39

    		Potassium Channel Neurological Disease
    TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease .
    TRAM-39
  • HY-P3316
    OSK-1

    		Potassium Channel Neurological Disease Inflammation/Immunology
    OSK-1 is a potent Kv channel blocker with IC50s of of 0.6 nM, 5.4 nM, 0.014 nM for Kv1.1, Kv1.2 and Kv1.3, respectively. OSK1 is a moderate blocker of Ca 2+-activated KCa3.1 channel with an IC50 of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent .
    OSK-1
  • HY-50694R
    Senicapoc (Standard)

    ICA-17043 (Standard)

    		 Potassium Channel Reference Standards Others
    Senicapoc (Standard) is the analytical standard of Senicapoc. This product is intended for research and analytical applications. Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM .
    Senicapoc (Standard)
  • HY-111655R
    SKA-31 (Standard)

    		Potassium Channel Cardiovascular Disease
    SKA-31 (Standard) is the analytical standard of SKA-31. This product is intended for research and analytical applications. SKA-31 is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure .
    SKA-31 (Standard)
  • HY-P1424A
    Lei-Dab7 TFA

    		Potassium Channel Neurological Disease
    Lei-Dab7 TFA is a high affinity, selective KCa2.2 (SK2) channel blocker (Kd=3.8 nM). Lei-Dab7 TFA exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, Kv and Kir2.1. Lei-Dab7 TFA increases theta-burst responses and increases LTP in rat hippocampal slices in vitro.
    Lei-Dab7 TFA
  • HY-RS26941
    Kcnn4 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Kcnn4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kcnn4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Kcnn4 Rat Pre-designed siRNA Set A
    Kcnn4 Rat Pre-designed siRNA Set A
  • HY-RS07172
    KCNN4 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    KCNN4 Human Pre-designed siRNA Set A contains three designed siRNAs for KCNN4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    KCNN4 Human Pre-designed siRNA Set A
    KCNN4 Human Pre-designed siRNA Set A
  • HY-107414R
    SKA-121 (Standard)

    		Reference Standards Potassium Channel Cardiovascular Disease
    SKA-121 (Standard) is the analytical standard of SKA-121 (HY-107414). This product is intended for research and analytical applications. SKA-121 is a selective KCa3.1 activator. SKA-121 exhibits EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively.
    SKA-121 (Standard)
  • HY-103308R
    TRAM-39 (Standard)

    		Reference Standards Potassium Channel Neurological Disease
    TRAM-39 (Standard) is the analytical standard of TRAM-39 (HY-103308). This product is intended for research and analytical applications. TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease .
    TRAM-39 (Standard)
  • HY-101360R
    1-EBIO (Standard)

    1-Ethyl-2-benzimidazolinone (Standard)

    		 Potassium Channel Reference Standards Cardiovascular Disease Neurological Disease Cancer
    1-EBIO (1-Ethyl-2-benzimidazolinone) (Standard) is the analytical standard of 1-EBIO (HY-101360). This product is intended for research and analytical applications. 1-EBIO is an activator of Ca 2+ sensitive K + channels wirh an EC50 of 136 μM for KCa3.1. 1-EBIO induces Cl - secretion, K + conductance, membrane hyperpolarization, and afterhyperpolarisation currents. 1-EBIO reduces epileptiform activity, seizure incidence, and rescues cells from Ionomycin (HY-13434)-induced death .
    1-EBIO (Standard)
  • HY-RS20432
    Kcnn4 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Kcnn4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kcnn4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Kcnn4 Mouse Pre-designed siRNA Set A
    Kcnn4 Mouse Pre-designed siRNA Set A

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