183815-75-0
183815-75-0
Chemical Structure
OSK-1
- CAS No.: 183815-75-0
- Formula:C177H300N56O46S8
- Molecular Weight:4205.17
SMILES: O=C1NC(CCCCCC(C2OC2)O)C(NC(C)(C)C(NC(CC3=CC=CC=C3)C(N4CCCC14)=O)=O)=O
Biological Activity: OSK-1 is a potent Kv channel blocker with IC50s of of 0.6 nM, 5.4 nM, 0.014 nM for Kv1.1, Kv1.2 and Kv1.3, respectively. OSK1 is a moderate blocker of Ca2+-activated KCa3.1 channel with an IC50 of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent[1].
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OSK-1 | OSK-1 is a potent Kv channel blocker with IC50s of of 0.6 nM, 5.4 nM, 0.014 nM for Kv1.1, Kv1.2 and Kv1.3, respectively. OSK1 is a moderate blocker of Ca2+-activated KCa3.1 channel with an IC50 of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent. | |||||||||||||||||||||
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References
Keywords
