6 Results for "

Lenalidomide-5-Br

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "Lenalidomide-5-Br" in MCE Product Catalog:

Cat. No.: HY-W072954
CAS No.: 1010100-26-1
Target:  

Ligands for E3 Ligase

Research Areas:  

Cancer

Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC .
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1
1 Cited Publications
Cat. No.: HY-P10899
Target:  

PROTACs TGF-beta/Smad

Research Areas:  

Endocrinology

ETTAC-2 is a LRG1 PROTAC degrader, degrading LRG1 via the ubiquitin-proteasome pathway with a DC50 value of 8.38 μM. ETTAC-2 penetrates damaged renal cells to reduce the extracellular secretion of LRG1. ETTAC-2 effectively inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated extracellular matrix proteins. ETTAC-2 degrades LRG1 within fibrotic kidneys and the efficacy in inhibiting the TGF-β-Smad3 pathway both in vitro and vivo. ETTAC-2 can be used for renal fibrosis research .
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Cat. No.: HY-W452755
CAS No.: 2243825-20-7
Target:  

Ligands for E3 Ligase

Research Areas:  

Cancer

(R)-Desamino lenalidomide-5-Br is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. (R)-Desamino lenalidomide-5-Br can be linked to a target protein ligand via a linker to form a PROTAC.
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Cat. No.: HY-W797329
CAS No.: 2829898-76-0
Target:  

Ligands for E3 Ligase

Research Areas:  

Cancer

(3S)Lenalidomide-5-Br is a ligand for E3 ubiquitinase. (3S)Lenalidomide-5-Br can be used to synthesize PROTAC Cbl-b-IN-1 (HY-159608) .
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Cat. No.: HY-176188
CAS No.: 3081612-41-8
Research Areas:  

Cancer

Lenalidomide-5-Br-amide-C2-Br is an E3 ligase ligand-linker conjugate. Lenalidomide-5-Br-amide-C2-Br can be used to synthesize PROTAC DDR1 degrader-1 (HY-176184) .
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Cat. No.: HY-183011
CAS No.: 2953426-96-3
Target:  

Ligands for E3 Ligase

Research Areas:  

Others

CRBN ligand-901 (5d in Scheme 2) is a ligand for Cereblon (CRBN). CRBN ligand-901 can be linked to target protein ligands (e.g., VP1 ligand-1) via a linker to form PROTAC molecules (e.g., Jun15702 (HY-182924)) .
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