2 Results for "

Lenalidomide-Pip-butyn

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Lenalidomide-Pip-butyn" in MCE Product Catalog:

Cat. No.: HY-169362
CAS No.: 2497589-76-9
Research Areas:  

Cancer

Lenalidomide-Pip-butyn is Lenalidomide (HY-A0003)-based E3 ligase ligand-linker conjugate, and is used in the recruitment of CRBN protein. Lenalidomide-Pip-butyn can be connected to the ligand for protein to form PROTACs, such as the PROTAC STAT3 degrader SD-436 (HY-169360) .
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1
1 Cited Publications
Cat. No.: HY-P10899
Target:  

PROTACs TGF-beta/Smad

Research Areas:  

Endocrinology

ETTAC-2 is a LRG1 PROTAC degrader, degrading LRG1 via the ubiquitin-proteasome pathway with a DC50 value of 8.38 μM. ETTAC-2 penetrates damaged renal cells to reduce the extracellular secretion of LRG1. ETTAC-2 effectively inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated extracellular matrix proteins. ETTAC-2 degrades LRG1 within fibrotic kidneys and the efficacy in inhibiting the TGF-β-Smad3 pathway both in vitro and vivo. ETTAC-2 can be used for renal fibrosis research .
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