1 Result for "

MEDI6383

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "MEDI6383" in MCE Product Catalog:

Efizonerimod alfa
Efizonerimod alfa
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Cat. No.: HY-P99911
CAS No.: 1635395-27-5
Synonyms: MEDI-6383

Target:  

Orexin Receptor (OX Receptor)

Research Areas:  

Inflammation/Immunology Cancer

Efizonerimod alfa (MEDI-6383) is a recombinant human OX40L IgG4P Fc fusion protein that assembles into a hexameric structure and exerts potent agonist activity upon binding to OX40. The activity of Efizonerimod alfa is enhanced by Fcγ receptor-mediated aggregation. Efizonerimod alfa binds to OX40 on the surface of activated T cells, induces NF-κB promoter activity in OX40-expressing T cells, and triggers the production of Th1-type cytokines, T cell proliferation, and resistance to regulatory T cell (Treg)-mediated suppression. Efizonerimod alfa enhances the cytolytic activity of tumor-reactive T cells and slows tumor growth in immunodeficient mice. Efizonerimod alfa induces the proliferation of CD4, CD8, and B cells in the peripheral blood of healthy non-human primates. Efizonerimod alfa can be used in the research of advanced solid malignancies and melanoma .
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