5 Results for "

NR2B9c

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "NR2B9c" in MCE Product Catalog:

8
Tat-NR2B9c
Tat-NR2B9c
0 Images
8 Cited Publications
Cat. No.: HY-P0117
CAS No.: 500992-11-0
Synonyms: Tat-NR2Bct; NA-1
Target:  

iGluR NO Synthase

Research Areas:  

Neurological Disease

Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
8
Tat-NR2B9c TFA
Tat-NR2B9c TFA
0 Images
8 Cited Publications
Cat. No.: HY-P0117A
CAS No.: 1834571-04-8
Synonyms: Tat-NR2Bct TFA; NA-1 TFA
Target:  

iGluR NO Synthase

Research Areas:  

Neurological Disease

Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
Tat-HA-NR2B9c
Tat-HA-NR2B9c
0 Images
Cat. No.: HY-P5947
Target:  

HIV

Research Areas:  

Neurological Disease

Tat-HA-NR2B9 contains a fragment of the cellmembrane transduction domain of HIV-1 Tat, a influenza virus hemagglutinin (HA) epitope-tag, and the C-terminal 9 amino acids of NR2B (NR2B9c). Tat-HA-NR2B9 reduces infarct size and improves neurological functions in ischemia-induced cerebral injury in the rats
Tat-NR2Baa
Tat-NR2Baa
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Cat. No.: HY-P2307
CAS No.: 847829-41-8
Target:  

iGluR NO Synthase

Research Areas:  

Neurological Disease

Tat-NR2BAA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95 .
Tat-NR2Baa TFA
Tat-NR2Baa TFA
0 Images
Cat. No.: HY-P2307A
Target:  

iGluR NO Synthase

Research Areas:  

Neurological Disease

Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA TFA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95 .
Assay Types