16 Results for "

Non-viral

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "Non-viral" in MCE Product Catalog:

44
44 Publications Verification
Cat. No.: HY-138170
CAS No.: 2036272-55-4
Purity:  99.81%
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
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19
19 Cited Publications
Cat. No.: HY-W127378
CAS No.: 144189-73-1
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .
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1 Cited Publications
Cat. No.: HY-139200
CAS No.: 104872-42-6
Purity:  ≥98.0%
DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo .
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1 Cited Publications
Cat. No.: HY-P2529
CAS No.: 940866-75-1
Target:  

Peptides

Research Areas:  

Others

Penetratin is a cell-penetrating peptides derived from a nonviral protein. Penetratin can powerfully enhance drug absorption. Penetratin can be used for drug delivery research in the treatment of various diseases .
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Cat. No.: HY-W007599
CAS No.: 2483-46-7
Target:  

Drug Derivative

Research Areas:  

Cancer

(S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid is a polypeptide derivative, can be used to synthesis multifunctional amphiphilic peptide dendrimer for non-viral gene delivery in cancer research. (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid can be used in the preparation of organic substances that enhance the luminescence intensity of alkaline phosphatase substrates .
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Cat. No.: HY-155882
CAS No.: 80506-64-5
Synonyms: mPEG750-NH2
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
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Cat. No.: HY-126437I
CAS No.: 25988-63-0
Poly-L-lysine hydrobromide (MW 1000-5000) is a homopolymer of L-lysine and a polycationic non-viral gene delivery vector. Poly-L-lysine hydrobromide (MW 1000-5000) forms complexes with plasmid DNA. Poly-L-lysine hydrobromide (MW 1000-5000) is applicable to relevant research on lung cancer .
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Cat. No.: HY-147087
CAS No.: 1318793-78-0
Purity:  ≥98.0%
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
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Cat. No.: HY-W010514
CAS No.: 1460-57-7
trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells .
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Cat. No.: HY-149037A
Purity:  98.60%
Synonyms: N4-Spermine cholesteryl carbamate pentahydrochloride
GL67 pentahydrochloride (N4-Spermine cholesteryl carbamate pentahydrochloride) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 pentahydrochloride enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 pentahydrochloride mediates the transduction of plasmid DNA into cells. GL67 pentahydrochloride can be used in drug delivery-related research .
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Cat. No.: HY-W322225
CAS No.: 59752-57-7
Synonyms: DLPE; 1,2-Dilauroyl-sn-glycero-3-PE
Target:  

Liposome

Research Areas:  

Others

1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE; 1,2-Dilauroyl-sn-glycero-3-PE) is an anionic phospholipid. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine promotes the endocytosis of liposome-DNA complexes into target cells, and subsequently mediates membrane fusion between liposome carriers and endosomes to deliver DNA into the nucleus. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a component of anionic artificial viral envelope liposomes, which deliver plasmid DNA to hepatoma cells without serum inhibition. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine enables the construction of biocompatible non-viral gene delivery vector systems. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is applicable for liposome synthesis .
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Cat. No.: HY-149037
CAS No.: 179075-30-0
Synonyms: N4-Spermine cholesteryl carbamate
GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 mediates the transduction of plasmid DNA into cells. GL67 can be used in drug delivery-related research .
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Cat. No.: HY-172166B
TRITC-lysine-dextran (MW 70kDa) is a fluorescent label prepared by the conjugation of TRITC (HY-D0791), lysine and dextran. TRITC-lysine-dextran (MW 70kDa) serves multiple functions as an axonal tracer, non-viral nanocarrier and fixable fluorescent clonal marker. TRITC-lysine-dextran (MW 70kDa) undergoes anterograde and retrograde transport within axons of sensory neurons, and acts as a non-viral delivery system to precisely deliver biomolecules to neurons. TRITC-lysine-dextran (MW 70kDa) remains stably retained during histological preparation, thereby supporting continuous observation in live or fixed samples .
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Cat. No.: HY-W010514R
CAS No.: 1460-57-7
trans-Cyclohexane-1,2-diol (Standard) is the analytical standard of trans-Cyclohexane-1,2-diol (HY-W010514). This product is intended for research and analytical applications. trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells .
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Cat. No.: HY-L039
3,197 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 3,197 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Cat. No.: HY-178736S
Synonyms: DLPE-d46; 1,2-Dilauroyl-sn-glycero-3-PE-d46
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine-d46 (DLPE-d46; 1,2-Dilauroyl-sn-glycero-3-PE-d46) is the deuterium labeled 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE; 1,2-Dilauroyl-sn-glycero-3-PE) is an anionic phospholipid. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine promotes the endocytosis of liposome-DNA complexes into target cells, and subsequently mediates membrane fusion between liposome carriers and endosomes to deliver DNA into the nucleus. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a component of anionic artificial viral envelope liposomes, which deliver plasmid DNA to hepatoma cells without serum inhibition. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine enables the construction of biocompatible non-viral gene delivery vector systems. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is applicable for liposome synthesis .
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