179075-30-0
Chemical Structure
GL67
Synonym(s): N4-Spermine cholesteryl carbamate
- CAS No.: 179075-30-0
- Formula:C38H70N4O2
- Molecular Weight:614.99
IUPAC Name: 5-amino-7-chloro-8-fluoro-2-(methylthio)pyrido[4,3-d]pyrimidin-4(3H)-one
InChIKey: KBBLYWGVXTZWCU-HMVYLTCSSA-N
SMILES: C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(N(CCCN)CCCCNCCCN)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C
Biological Activity: GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 mediates the transduction of plasmid DNA into cells. GL67 can be used in drug delivery-related research[1][2].
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GL67 | GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 mediates the transduction of plasmid DNA into cells. GL67 can be used in drug delivery-related research. | |||||||||||||||||||||
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- [1]. Jarallah SJ, et al. GL67 lipid-based liposomal formulation for efficient siRNA delivery into human lung cancer cells. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. 2023 Jul;31(7):1139-1148. [Content Brief]
- [2]. Jiang C, et al. Efficiency of cationic lipid-mediated transfection of polarized and differentiated airway epithelial cells in vitro and in vivo. Human gene therapy. 1998 Jul 20;9(11):1531-42. [Content Brief]
Keywords
