1 Result for "

OM-7D3-B3

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "OM-7D3-B3" in MCE Product Catalog:

OM-7D3-B3
OM-7D3-B3
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Cat. No.: HY-P991200

Target:  

HCV Claudin

Domaines de recherche:  

Infection

OM-7D3-B3 is an antibody-based antiviral agent targeting the tight junction protein CLDN1 (Kd=4 nM). By binding to the first extracellular domain of CLDN1, OM-7D3-B3 disrupts the formation of the CLDN1-CD81 co-receptor complex, thereby effectively inhibiting the entry of hepatitis C virus (HCV). OM-7D3-B3 not only prevents de novo and chronic HCV infections in humanized liver chimeric mice and uPA-SCID mice transplanted with human livers, but also exhibits favorable safety with no toxic effects observed. OM-7D3-B3 serves as a critical tool for research on HCV infection mechanisms and antiviral drug development .
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