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PIP3

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By Targets:	Akt (2) Apoptosis (5) Biochemical Assay Reagents (2) Btk (1) DNA/RNA Synthesis (1) Drug Derivative (3) E3 Ligase Ligand-Linker Conjugates (2) Endogenous Metabolite (1) Fluorescent Dye (1) LYTACs (1) PD-1/PD-L1 (1) PI3K (11) PKC (1) PSMA (2) Reactive Oxygen Species (ROS) (1) Reference Standards (2) TGF-β Receptor (1)
By Research Areas:	Cancer (14) Inflammation/Immunology (2) Metabolic Disease (2)

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Targets Recommended: PI5P4K

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15244

Alpelisib Maximum Cited Publications 125 Publications Verification BYL-719	PI3K Apoptosis	Cancer
Alpelisib (BYL-719) is an orally active PI3Kα-selective inhibitor that blocks the conversion of *PIP2* to *PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch* and JAK-STAT. Alpelisib also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome ^[3] .

HY-101562

Inavolisib 5+ Cited Publications GDC-0077; RG6114	PI3K Apoptosis	Cancer
Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kα inhibitor (IC₅₀=0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib can be used for the study of breast cancer .

HY-A0183

Phosphatidylserine 1 Publications Verification Phospholipids, phosphatidylserines; Serine glycerophosphatides	Akt TGF-β Receptor	Inflammation/Immunology
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses ^[3] .

HY-15244A

Alpelisib hydrochloride Maximum Cited Publications 125 Publications Verification BYL-719 hydrochloride	PI3K Apoptosis	Cancer
Alpelisib (BYL-719) hydrochloride is an orally active PI3Kα-selective inhibitor that blocks the conversion of *PIP2* to *PIP3, thereby inhibiting pathways including PI3K/AKT/mTOR, MAPK/ERK, Notch* and JAK-STAT. Alpelisib hydrochloride also induces apoptosis, G0/G1 phase arrest and senescence; it significantly inhibits the proliferation, self-renewal, stemness and epithelial-mesenchymal transition (EMT) of tumor cells, reduces cancer stem cell populations and decreases the expression of stem cell markers. Alpelisib hydrochloride not only enhances the sensitivity to Eribulin (HY-13442) and exerts a synergistic effect with Paclitaxel (HY-B0015), but may also induce drug resistance by upregulating the SGK3/GSK3β/β-catenin signaling pathway. Alpelisib hydrochloride can be applied to research related to breast cancer, gastric cancer and lipomas associated with PTEN hamartoma tumor syndrome ^[3] .

HY-165099

C-8 Ceramide-1-phosphate	Apoptosis PI3K DNA/RNA Synthesis	Metabolic Disease
C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate *PI3-K, which in turn produces PIP3; PIP3* can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis .

HY-103224

PIT-1	PI3K	Cancer
PIT-1 is a selective *PIP3* (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo .

HY-148971A

PtdIns-(345)-P3 (12-dipalmitoyl) sodium Phosphatidylinositol tris-3,4,5-phosphate, 1,2-dipalmitoyl sodium	Drug Derivative	Others
PtdIns-(345)-P3 (12-dipalmitoyl) sodium (Phosphatidylinositol tris-3,4,5-phosphate, 1,2-dipalmitoyl sodium) is a phosphatidylinositol 3,4,5-trisphosphate (PIP3) analog. PtdIns-(345)-P3 (12-dipalmitoyl) sodium can be incorporated in liposomes establish a backdrop of membrane phospholipids that closely mirrors in vivo conditions .

HY-N15978

*18:1-12:0 Biotin PIP3* tetrasodium**	Biochemical Assay Reagents	Others
18:1-12:0 Biotin PIP3 tetrasodium is a biotinylated lipid.

HY-W127317

Inositol 1,3,4,5-tetraphosphate	Biochemical Assay Reagents	Others
Inositol 1,3,4,5-tetraphosphate is the head group of PIP3 (phosphatidylinositol 3,4,5-trisphosphate) .

HY-124535

TGX-115	PI3K	Metabolic Disease
TGX-115 is a p110β/p110δ-selective, *PI3-K* inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated *PI(3,4)P2* and *PIP3* levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus .

HY-124348

DM-PIT-1 3,5-Dimethyl PIT-1	PI3K	Cancer
DM-PIT-1 is a **PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin)** interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer .

HY-106006

RV-1729	PI3K	Others Inflammation/Immunology
RV-1729 is an inhibitor of the phosphatidylinositol 3-kinase-δ (PI3Kδ). RV-1729 identifies inhibition of the PI3K isotype by quantifying the release of phosphatidylinositol 3,4, 5-triphosphate (PIP3) (IC₅₀=12 nM), showing twice the selectivity for PI3Kδ relative to PI3Kγ. RV-1729 is also 16 times more selective to PI3Kα. RV-1729 regulates immune and inflammatory responses by inhibiting PI3Kδ. RV-1729 can be used in studies of asthma and chronic obstructive pulmonary disease (COPD) .

HY-172366

BQ0413	PSMA	Cancer
BQ0413 exhibits good affinity to PSMA with a K_D of 89 pM. BQ0413 exhibits good uptake and internalization property with an internalization rate of 44% in PC3-pip cell. BQ0413 can be used as tumor imaging agent when labeled with 99mTc .

HY-171558

PI3K-IN-56	PI3K Akt	Cancer
PI3K-IN-56 (Compound 1) is an orally active, potent and selective irreversible inhibitor of phosphoinositide 3-kinase (PI3K). PI3K-IN-56 irreversibly blocks the phosphatidylinositol-3,4,5-triphosphate (PIP3) production and downstream AKT signaling pathway. PI3K-IN-56 is promising for research of PI3Kα-driven cancers, such as breast and ovarian cancers .

HY-175086

PtdIns-(3,4,5)-P3-fluorescein triethylammonium DOPI-3,4,5-P3-fluorescein triethylammonium; PI(3,4,5)P3-fluorescein triethylammonium; PIP3[3',4',5']-fluorescein triethylammonium	Fluorescent Dye	Others
PtdIns-(3,4,5)-P3 is a second messenger. PtdIns-(3,4,5)-P3-fluorescein triethylammonium is a fluorescent probe that can detect any protein that has a high-affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids .

HY-180884

BTK-IN-46	Btk	Cancer
BTK-IN-46 (compound 24) is a reversible covalent BTK inhibitor. BTK-IN-46 covalently labels a lysine in the inositol phosphate (PIP3) binding site, thereby blocking Pleckstrin homology (PH) domain-mediated membrane recruitment and activation of BTK .

HY-179543

PtdIns-(3,4,5)-P3-(1-stearoyl, 2-arachidonoyl) sodium	Endogenous Metabolite	Others
PtdIns-(3,4,5)-P3-(1-stearoyl, 2-arachidonoyl) sodium is a specific molecular form of phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 is the core lipid messenger in the tyrosine kinase pathway, regulating cell proliferation, survival and metabolism by recruiting effector proteins. Its abnormality is associated with cancer. PtdIns-(3,4,5)-P3-(1-stearoyl, 2-arachidonoyl) sodium can be used for studying lipid signal transduction .

HY-103224R

PIT-1 (Standard)	Reference Standards PI3K	Cancer
PIT-1 (Standard) is the analytical standard of PIT-1. This product is intended for research and analytical applications. PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo .

HY-E70855

PKCζ Recombinant Human Active Protein Kinase	PKC	Cancer
PKCζ is a member of the atypical PKC subfamily and has been widely implicated in the regulation of cellular functions. The major activation pathway of PKCζ depends on phosphatidylinositol (PI)-3,4,5-trisphosphate (PIP(3)), which is mainly produced by PI-3 kinase. PKCζ Recombinant Human Active Protein Kinase is a recombinant PKCζ protein that can be used to study PKCζ-related functions .

HY-101562R

Inavolisib (Standard) GDC-0077 (Standard); RG6114 (Standard)	PI3K Reference Standards Apoptosis	Cancer
Inavolisib (Standard) is the analytical standard of Inavolisib (HY-101562). This product is intended for research and analytical applications. Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kα inhibitor (IC50=0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib can be used for the study of breast cancer .

HY-W1114864

*(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W1114864A

*(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid hydrochloride*	E3 Ligase Ligand-Linker Conjugates	Cancer
(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-181830

Atz-L5	PD-1/PD-L1 PSMA LYTACs	Cancer
Atz-L5 is a PD-L1 PTAC (PSMA-targeted chimera) degrader (DC₅₀: 18 pM in PC3-PIP cells; 2 pM in LNCaP cells) and LYTAC. Atz-L5 promotes lysosomal degradation of PD-L1 in PSMA-positive prostate cancer cells. Atz-L5 is applicable to the research of prostate cancer .

HY-148965A

PtdIns-(3)-P1 (1,2-dipalmitoyl) ammonium DPPI-3-P ammonium; PIP[3'](16:0/16:0) ammonium; PI(3)P (16:0/16:0) ammonium	Drug Derivative Reactive Oxygen Species (ROS)	Others
PtdIns-(3)-P1 (1,2-dipalmitoyl) (Compound 7) ammonium is a derivative of phosphatidylinositol 3-phosphate (PtdIns(3)P). phosphatidylinositol 3-phosphate can bind to the FYVE domain of human EEA1 and act as a second messenger in cellular signaling and membrane trafficking. phosphatidylinositol 3-phosphate can stimulate ROS formation by regulating the neutrophil oxidase complex ^[3].

HY-175089

PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) sodium DOPI-3,4,5-P3 sodium; PIP3[3',4',5'](8:0/8:0) sodium; PI(3,4,5)P3 (8:0/8:0) sodium	Drug Derivative	Others
PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (DOPI-3,4,5-P3) sodium is an analog of phosphatidylinositol .

Cat. No.	Product Name	Type

HY-165099

C-8 Ceramide-1-phosphate	Biochemical Assay Reagents
C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate *PI3-K, which in turn produces PIP3; PIP3* can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis .

C-8 Ceramide-1-phosphate

Biochemical Assay Reagents

C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate PI3-K, which in turn produces PIP3; PIP3 can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0183

Phosphatidylserine 1 Publications Verification Phospholipids, phosphatidylserines; Serine glycerophosphatides	Animals Source Classification	Akt TGF-β Receptor
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses ^[3] .

HY-N15978

*18:1-12:0 Biotin PIP3* tetrasodium**	Lipid	Biochemical Assay Reagents
18:1-12:0 Biotin PIP3 tetrasodium is a biotinylated lipid.

HY-W127317

Inositol 1,3,4,5-tetraphosphate	Microorganisms Source Classification	Biochemical Assay Reagents
Inositol 1,3,4,5-tetraphosphate is the head group of PIP3 (phosphatidylinositol 3,4,5-trisphosphate) .

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PIP3

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