158983-53-0
Chemical Structure
C-8 Ceramide-1-phosphate
- CAS No.: 158983-53-0
- Formula:C26H52NO6P
- Molecular Weight:505.67
InChIKey: VSSNYUXSRXINIP-WRBRXSDHSA-N
SMILES: CCCCCCCC(N[C@@H](COP(O)(O)=O)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
Biological Activity:
C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate PI3-K, which in turn produces PIP3; PIP3 can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis[1][2].
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C-8 Ceramide-1-phosphate | C-8 Ceramide-1-phosphate is a cell apoptosis inhibitor and a cell survival inducer that can stimulate DNA synthesis and cell division. C-8 Ceramide-1-phosphate can inhibit acidic sphingomyelinase (SMase) and stimulate PI3-K, which in turn produces PIP3; PIP3 can also inhibit acidic SMase. The C-8 Ceramide-1-phosphate and ceramide can be interconverted in cells through kinase and phosphatase activity, and maintaining the balance between the two is crucial for cellular and tissue homeostasis. |
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- [1]. Gomez-Muñoz A, et al. Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides. Mol Pharmacol. 1995 May;47(5):833-9. PMID: 7746276. [Content Brief]
- [2]. Gómez-Muñoz A. Ceramide 1-phosphate/ceramide, a switch between life and death. Biochim Biophys Acta. 2006 Dec;1758(12):2049-56. [Content Brief]
Keywords
