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C8-Ceramide (Synonyms: N-Octanoyl-D-erythro-sphingosine)

Cat. No.: HY-108391 Purity: >98.0%
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C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a synthetic cell-permeable analog of endogenous ceramides, interfered with cell proliferation, and was cytotoxic to papilloma virus-containing human cervix carcinoma cells. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections.

For research use only. We do not sell to patients.

C8-Ceramide Chemical Structure

C8-Ceramide Chemical Structure

CAS No. : 74713-59-0

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Description

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a synthetic cell-permeable analog of endogenous ceramides, interfered with cell proliferation, and was cytotoxic to papilloma virus-containing human cervix carcinoma cells. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections[1][2].

In Vitro

C8-ceramide (3 μM; 48 hours) markedly reduces the tumor cell number after 48 h of treatment, an effect that endured even after the removal of C8-ceramide[1].
C8-ceramide-mediated cytotoxicity is not relevant for the apoptotic cell death[1].
C8-ceramide is capable of producing a necrosis-like cell death[1].
C8-ceramide does not induce caspase-dependent cleavage of PARP in tumor cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: CALO cells, INBL cells, HeLa cells
Concentration: 3 μM
Incubation Time: 48 hours
Result: Markedly reduced the tumor cell number.
In Vivo

C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8+ and CD4+ T cell responses to viral infections in virus infected mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice, with lymphocytic choriomeningitis virus infected[2]
Dosage: 0.1 mg/kg
Administration: Intranasal administration
Result: Increased the CD8+ T cell response to influenza in the lungs.
Molecular Weight

425.69

Formula

C₂₆H₅₁NO₃

CAS No.

74713-59-0

SMILES

CCCCCCCC(N[[email protected]@H](CO)[[email protected]](O)/C=C/CCCCCCCCCCCCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: >98.0%

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Keywords:

C8-CeramideN-Octanoyl-D-erythro-sphingosineOthersceramidesanalogcellproliferationcytotoxicdendriticcellsDCsactivationmaturationInhibitorinhibitorinhibit

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C8-Ceramide
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HY-108391
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