2633645-58-4
2633645-58-4
Chemical Structure
PI3K-IN-56
- CAS 番号: 2633645-58-4
- Formula:C28H32F3N9O5
- Molecular Weight:631.61
SMILES: O=C(NC1=CC(C(F)(F)F)=C(C2=NN3C=C(CN4CCN(CC4)C(CNC(C=C)=O)=O)C=C3C(N5CCOCC5)=N2)C=N1)OC
Biological Activity: PI3K-IN-56 (Compound 1) is an orally active, potent and selective irreversible inhibitor of phosphoinositide 3-kinase (PI3K). PI3K-IN-56 irreversibly blocks the phosphatidylinositol-3,4,5-triphosphate (PIP3) production and downstream AKT signaling pathway. PI3K-IN-56 is promising for research of PI3Kα-driven cancers, such as breast and ovarian cancers[1].
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PI3K-IN-56 | PI3K-IN-56 (Compound 1) is an orally active, potent and selective irreversible inhibitor of phosphoinositide 3-kinase (PI3K). PI3K-IN-56 irreversibly blocks the phosphatidylinositol-3,4,5-triphosphate (PIP3) production and downstream AKT signaling pathway. PI3K-IN-56 is promising for research of PI3Kα-driven cancers, such as breast and ovarian cancers. | |||||||||||||||||||||
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