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Results for "

PK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA-PK (67) 5-HT Receptor (4) Akt (4) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (4) Apoptosis (22) ATM/ATR (7) Aurora Kinase (1) Autophagy (12) Bacterial (11) Bcr-Abl (1) BCRP (3) Beta-secretase (1) Biochemical Assay Reagents (4) c-Fms (3) c-Kit (1) c-Met/HGFR (1) Casein Kinase (2) Caspase (3) CD28 (1) CDK (2) Checkpoint Kinase (Chk) (1) COX (1) Dengue Virus (1) Dipeptidyl Peptidase (2) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (5) Dopamine Receptor (1) Drug Derivative (1) Drug Metabolite (1) EGFR (5) Endogenous Metabolite (3) Epigenetic Reader Domain (2) ERK (1) Factor Xa (1) FAK (1) FGFR (1) Flavivirus (1) FLT3 (4) Fluorescent Dye (5) FOXO (1) Fungal (2) GABA Receptor (10) GHSR (1) Glucosylceramide Synthase (GCS) (1) GLUT (1) Glycosidase (1) GPR84 (1) GSK-3 (1) HBV (2) HCV (1) HCV Protease (1) HDAC (1) Histone Methyltransferase (1) HSV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) IRAK (3) Isotope-Labeled Compounds (4) JNK (2) Keap1-Nrf2 (1) LPL Receptor (1) LRRK2 (1) MDM-2/p53 (10) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) mTOR (22) nAChR (1) Neurokinin Receptor (1) NF-κB (2) P-glycoprotein (1) p38 MAPK (1) Parasite (3) PARP (3) PDGFR (4) Phosphodiesterase (PDE) (1) PI3K (27) PKA (3) Poly(ADP-ribose) Glycohydrolase (PARG) (2) Potassium Channel (3) Prokineticin Receptor (2) Prostaglandin Receptor (2) PROTACs (1) PSMA (1) Pyruvate Kinase (7) Reactive Oxygen Species (ROS) (2) Reference Standards (18) Ribosomal S6 Kinase (RSK) (1) RIP kinase (1) ROR (1) RXFP Receptor (1) SARS-CoV (1) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (4) Sodium Channel (8) Src (3) STAT (1) STING (1) TAM Receptor (2) Thrombin (1) TNF Receptor (1) Trk Receptor (1) URAT1 (2) VEGFR (3) α-synuclein (1) γ-secretase (2)
By Research Areas:	Cancer (122) Cardiovascular Disease (7) Endocrinology (2) Infection (27) Inflammation/Immunology (18) Metabolic Disease (13) Neurological Disease (35)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Phospholipids (1) Human Pre-designed siRNA Sets (2) Antisense Oligonucleotides (2) siRNAs (4)

217

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

GMP Molecules

Targets Recommended: DNA-PK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10108

LY294002 Maximum Cited Publications 1120 Publications Verification	PI3K Casein Kinase DNA-PK Apoptosis Autophagy	Infection Cancer
LY294002 is a broad-spectrum inhibitor of PI3K with IC₅₀s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively . LY294002 also inhibits CK2 with an IC₅₀ of 98 nM . LY294002 is a competitive *DNA-PK* inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC₅₀ of 1.4 μM. LY294002 is an apoptosis activator .

HY-111783

AZD-7648 45+ Cited Publications	DNA-PK ATM/ATR PI3K Apoptosis	Cancer
AZD-7648 is a potent, orally active, selective *DNA-PK* inhibitor with an IC₅₀ of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity .

HY-B0211

Riluzole 10+ Cited Publications PK 26124	Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-19567

PK 11195 5+ Cited Publications RP 52028	Parasite	Infection
PK 11195 (RP 52028) is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC₅₀s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.

HY-109509

Enoxaparin 1 Publications Verification PK 10169; Enoxaparin sodium	Factor Xa Thrombin SARS-CoV	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19 .

HY-12689

Mitapivat 3 Publications Verification AG-348	Pyruvate Kinase	Metabolic Disease
Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency .

HY-B0211A

Riluzole hydrochloride 10+ Cited Publications PK 26124 hydrochloride	Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-147056

PKRA83 PKRA7	Prokineticin Receptor	Neurological Disease Inflammation/Immunology Cancer
PKRA83 (PKRA7) is a potent prokineticin (PK2) antagonist, which can compete for the binding of PK2 to its receptors PKR1 and PKR2. PKRA83 potently inhibits PK2 receptors, with IC₅₀ values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 has anticancer, anti-arthritis and anti-angiogenic activities. .

HY-15719

NU 7026 10+ Cited Publications LY293646	DNA-PK Apoptosis	Cancer
NU 7026 (LY293646) is a novel specific *DNA-PK* inhibitor with IC₅₀ of 0.23 μM, also inhibits PI3K with IC₅₀ of 13 μM.

HY-13281

PIK-75 hydrochloride 5 Publications Verification	DNA-PK PI3K Apoptosis	Cancer
PIK-75 hydrochloride is a reversible *DNA-PK* and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC₅₀s of 2, 5.8 and 76 nM, respectively. PIK-75 hydrochloride inhibits p110α >200-fold more potently than p110β (IC₅₀=1.3 μM) . PIK-75 hydrochloride induces apoptosis .

HY-12030

PIK-90 5 Publications Verification	PI3K DNA-PK	Cancer
PIK-90 is a *DNA-PK* and PI3K inhibitor, which inhibits p110α, p110γ and *DNA-PK* with IC₅₀s of 11, 18 and 13 nM, respectively.

HY-10372

PP121 4 Publications Verification	mTOR PDGFR VEGFR Src Apoptosis	Cancer
PP121 is a multi-targeted kinase inhibitor with IC₅₀s of 10, 60, 12, 14, 2 nM for mTOR, *DNK-PK, VEGFR2, Src, PDGFR*, respectively.

HY-P2806

Pyruvate Kinase, Microorganism PK; Fluorokinase	Endogenous Metabolite	Metabolic Disease Cancer
Pyruvate Kinase, Microorganism (PK) is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP .

HY-P99143

Anti-Mouse NK1.1 Antibody (PK136)	Neurokinin Receptor NF-κB STAT	Inflammation/Immunology
Anti-Mouse NK1.1 Antibody (PK136) is an anti-mouse NK1.1 IgG2a monoclonal antibody. Anti-Mouse NK1.1 Antibody (PK136) can deplete natural killer (NK) cells. Anti-Mouse NK1.1 Antibody (PK136) inhibits the JAK-STAT and NF-κB signaling pathways. Anti-Mouse NK1.1 Antibody (PK136) can be used for research on inflammation conditions such as non-alcoholic steatohepatitis (NASH) .

HY-117389

Homocarbonyltopsentin PK4C9	DNA/RNA Synthesis	Others
Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC₅₀ value of 16 μM .

HY-109190

Seralutinib 2 Publications Verification GB002; PK10571	PDGFR c-Fms c-Kit	Cardiovascular Disease
Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC₅₀s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension .

HY-128784

PK11007	MDM-2/p53 Reactive Oxygen Species (ROS)	Cancer
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .

HY-U00447

PK11000	MDM-2/p53 DNA Alkylator/Crosslinker	Cancer
PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities .

HY-128348

PK68	RIP kinase	Inflammation/Immunology Cancer
PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC₅₀ of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis .

HY-133119

PK150	Bacterial	Infection
PK150, an analogue of Sorafenib, shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 μM, respectively .

HY-101667

LTURM34 5 Publications Verification	DNA-PK	Cancer
LTURM34 is a specific *DNA-PK* inhibitor (IC₅₀=34 nM). LTURM34 exhibits 170-fold selectivity for DNA-PK over PI3K. LTURM34 shows potent antiproliferative activity in a wide range of tumor cell lines .

HY-13431

KU-0060648 4 Publications Verification	DNA-PK PI3K mTOR	Cancer
KU-0060648 is a dual inhibitor of PI3K and *DNA-PK* with IC₅₀s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively .

HY-19341

Compound 401 1 Publications Verification	DNA-PK	Cancer
Compound 401 is a synthetic inhibitor of *DNA-PK* (IC₅₀ = 0.28 μM) that also targets mTOR but not PI3K in vitro.

HY-107834

PIK-75 5 Publications Verification	DNA-PK PI3K Apoptosis	Cancer
PIK-75 is a reversible *DNA-PK* and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC₅₀s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC₅₀=1.3 μM) . PIK-75 induces apoptosis .

HY-P2806A

Pyruvate Kinase (PK),Rabbit Muscle ATP:Pyruvate 2-0-phosphotransferase,PK	Pyruvate Kinase	Metabolic Disease Cancer
Pyruvate Kinase (PK),Rabbit Muscle (ATP:Pyruvate 2-0-phosphotransferase,PK) is a biological material or organic compound that can be used in life science research .

HY-110083

PK44 phosphate	Dipeptidyl Peptidase	Metabolic Disease
PK44 phosphate is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ value of 15.8 nM .

HY-120122

PK7088	MDM-2/p53	Cancer
PK7088 is a pyrazole and a specific peptide. PK7088 supports the reactivation of mutant p53 by converting it to a form exhibiting wild-type properties. PK7088 exhibit anticancer activity in cancer research .

HY-110184

PK-THPP	Potassium Channel	Neurological Disease
PK-THPP is a potent and brain-penetrant TWIK-related acid-sensitive K ⁺ ion channel (K2P9.1 or TASK-3) blocker with IC₅₀s of 35 nM and 300 nM for TASK-3 and TASK-1, respectively. PK-THPP shows no or less activity against other K ⁺ channels. PK-THPP is an effective breathing stimulant and can be used for the study of breathing disorders .

HY-157700

Hexadecenyl-2-hydroxy-sn-glycero-3-PC C16(Plasm) LPC; Lysophosphatidylcholine 16:0p/0:0	Biochemical Assay Reagents	Neurological Disease
Hexadecenyl-2-hydroxy-sn-glycero-3-PC (C16(Plasm) LPC) is a phosphatidylcholine. Hexadecenyl-2-hydroxy-sn-glycero-3-PC prolongs the lag-phase of α-syn aggregation, and can be used in Parkinson’s disease research .

HY-100140

Pipequaline 1 Publications Verification PK-8165	GABA Receptor	Neurological Disease
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity .

HY-U00433A

JMV 2959 hydrochloride 3 Publications Verification	GHSR	Neurological Disease Endocrinology
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32±3 nM in LLC-PK₁ cells.

HY-153767

PK095	MDM-2/p53	Cancer
PK095 is a p53 mutant stabilizer. PK095 can be used for research of cancer .

HY-B0211R

Riluzole (Standard) PK 26124 (Standard)	Reference Standards Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole (Standard) is the analytical standard of Riluzole. This product is intended for research and analytical applications. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-142471A

ZL-2201	DNA-PK	Cancer
ZL-2201 is a potent *DNA-PK* inhibitor with an IC₅₀ of 1 nM (WO2021104277A1, compound 5) .

HY-19939S2

(R)-VX-984 (R)-M9831	DNA-PK	Others
(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent DNA-PK inhibitor.

HY-18650

KU 59403 1 Publications Verification	ATM/ATR	Cancer
KU 59403 is a potent ATM inhibitor, with IC₅₀ values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively .

HY-103434

PK44	Dipeptidyl Peptidase	Metabolic Disease
PK44 (Compound 67) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ value of 15.8 nM. PK44 is promising for research of diabetes .

HY-163134

DNA-PK-IN-12	DNA-PK	Cancer
DNA-PK-IN-12 (compound 31t) is an oral active *DNA-PK* inhibitor with the IC₅₀ of 0.1 nM. DNA-PK-IN-12 inhibits cell growth and Hct116 cell colony formation with the IC₅₀ of 33.28 μM, and shows antitumor activity in vivo .

HY-146565

DNA-PK-IN-8	DNA-PK	Cancer
DNA-PK-IN-8 is a highly potent, selective and orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ value of 0.8 nM. DNA-PK-IN-8 exhibits synergistic antiproliferative activity against a series of cancer cell lines and significantly suppresses HL-60 tumor growth, when using in combination with Doxorubicin .

HY-145937

PK9327	MDM-2/p53	Cancer
PK9327 is a small-molecule stabilizer targeting cavity-creating p53 cancer mutations.

HY-142471

ZL-2201 free base	DNA-PK	Cancer
ZL-2201 free base is a potent *DNA-PK* inhibitor with an IC₅₀ of 1 nM (WO2021104277A1, compound 5) .

HY-100707

IC 86621	DNA-PK Apoptosis	Inflammation/Immunology Cancer
IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC₅₀ of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC₅₀=68 µM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis .

HY-156090

PK-10	Mitochondrial Metabolism Fungal	Infection
PK-10 is a synergistic antibacterial agent of Fluconazole (HY-B0101) and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction .

HY-144037

DNA-PK-IN-4	DNA-PK	Cancer
DNA-PK-IN-4 is a potent inhibitor of *DNA-PK*. DNA-PK-IN-4 is a imidazolinone derivative compound. DNA-PK-IN-4 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-4 has the potential for the research of cancer disease (extracted from patent WO2021209055A1, compound 27) .

HY-B0211S1

Riluzole-13C6 PK 26124-¹³C₆	Isotope-Labeled Compounds Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole- ¹³C₆ (PK 26124- ¹³C₆) is ¹³C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-170553

ZPD-2	α-synuclein	Neurological Disease
ZPD-2 inhibits the aggregation of C-terminally truncated and full-length α-synuclein. ZPD-2 inhibits the formation and fibrillation of α-Syn, thereby preventing its propagation. ZPD-2 can be used in research of Parkinson's disease .

HY-168446

PKR-IN-1	Pyruvate Kinase Fungal	Infection
PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor that has antifungal activity, with an EC₅₀ of 0.21 μg/mL for R. solani .

HY-121648

PK 130	Biochemical Assay Reagents	Cancer
PK 130 is a 2-nitroimidazole derivative that has radiosensitizing effects on hypoxic cells. PK 130 increases the radiosensitivity of Chinese hamster V79 cells under hypoxic conditions .

HY-100140A

Pipequaline hydrochloride 1 Publications Verification PK-8165 hydrochloride	GABA Receptor	Neurological Disease
Pipequaline hydrochloride (PK-8165 hydrochloride) is a partial benzodiazepine receptor agonist with anxiolytic activity .

HY-153943

DNA-PK-IN-10	DNA-PK	Cancer
DNA-PK-IN-10 is a *DNA-PK* inhibitor. DNA-PK-IN-10 can be used for the research of breast cancer and non-small cell lung cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W000800

cis,cis-Muconic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Bacterial
cis,cis-Muconic acid is a dicarboxylic acid produced by Saccharomyces cerevisiae. cis,cis-Muconic acid shows pH-dependent toxicity against Saccharomyces cerevisiae CEN.PK113-7D. cis,cis-Muconic acid can be used as intermediate for the production of various plastics and polymers .

HY-N2757

7-Ketositosterol	Structural Classification Plants Moraceae Steroids Morus alba Linn. Source Classification	Apoptosis
7-Ketositosterol is a phytosterol isolated from the fruits of the mulberry tree (Morus alba L.). 7-Ketositosterol can significantly inhibit Cisplatin (HY-17394)-induced apoptosis in LLC-PK1 cells and has the potential to improve Cisplatin-induced nephrotoxicity .

HY-N15451

Deoxytopsentin	Structural Classification Alkaloids Marine natural products Sponge Indole Alkaloids Source Classification	Pyruvate Kinase
Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro .

HY-122379

8-Hydroxypinoresinol	Oleaceae Lignans Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Source Classification	Reactive Oxygen Species (ROS)
8-Hydroxypinoresinol is a tetrahydrofurofuran lignan that has cytoprotective effects against peroxynitrite-induced LLC-PK1 cell damage .

HY-W000800R

cis,cis-Muconic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Bacterial
cis,cis-Muconic acid (Standard) is an analytical standard for cis,cis-Muconic acid (HY-W000800). This product is used for research and analytical applications. cis,cis-Muconic acid is a dicarboxylic acid produced by Saccharomyces cerevisiae. cis,cis-Muconic acid shows pH-dependent toxicity against Saccharomyces cerevisiae CEN.PK113-7D. cis,cis-Muconic acid can be used as intermediate for the production of various plastics and polymers .

HY-N14428

Fosfocytocin	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Fosfocytocin is found in the strain of Pseudomonas fluorescens PK-52. Fosfocytocin has very weak antibacterial activity .

Cat. No.	Product Name	Chemical Structure

HY-19939S

VX-984 4 Publications Verification
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .

HY-19939S2

(R)-VX-984
(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent DNA-PK inhibitor.

HY-B0960S

Sulfabenzamide-d4

Sulfabenzamide (N-Sulfanilylbenzamide)-d₄ is the deuterium labeled Sulfabenzamide (HY-B0960). Sulfabenzamide is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections .

HY-B0211S1

Riluzole-13C6
Riluzole- ¹³C₆ (PK 26124- ¹³C₆) is ¹³C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-B0211S

Riluzole-13C,15N2
Riluzole- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Riluzole . Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM .

HY-117259S

Valiltramiprosate-d6

Valiltramiprosate-d₆ (ALZ-801-d₆) is deuterium labeled Valiltramiprosate. ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound . ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease .

HY-B1658BS

Frovatriptan-d3 succinate

Frovatriptan-d₃ (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research .

Targets Recommended: DNA-PK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111783G

AZD-7648	DNA-PK ATM/ATR PI3K Apoptosis	Cancer
AZD-7648 (GMP) is AZD-7648 (HY-111783) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AZD-7648 is a potent, orally active, selective *DNA-PK* inhibitor with an IC₅₀ of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity .

HY-101570G

Nedisertib Peposertib; M3814	DNA-PK BCRP	Cancer
Nedisertib (GMP) (Peposertib (GMP)) is Nedisertib (HY-101570) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Nedisertib is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity .

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