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Results for "

PRB

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

2

Screening Libraries

1

Recombinant Proteins

13

Antibodies

7

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-158106
    AZD8421
    1 Publications Verification

    CDK Cancer
    AZD8421 is a selective CDK2 inhibitor (IC50 = 9 nM) as well as achieving CDK family selectivity in cells versus key off-targets (CDK1, CDK4/6, CDK9), AZD8421 had no significant kinase inhibition outside the CDK family. AZD8421 inhibits cancer cell proliferation by inhibiting pRB phosphorylation, inducing cell cycle arrest in G1/S phase and senescence. AZD8421 can be studied in research for breast cancer and ovarian cancer .
    AZD8421
  • HY-129180

    PROTACs CDK Cancer
    XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity, which consists of ligands for von Hippel-Lindau and CDK .
    XY028-133
  • HY-162318
    MYC degrader 1
    1 Publications Verification

    Molecular Glues c-Myc Cancer
    MYC degrader 1 (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. MYC degrader 1 restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors .
    MYC degrader 1
  • HY-112158
    NSC139021
    1 Publications Verification

    ERGi-USU

    RIO Kinase Cancer
    NSC139021 (ERGi-USU) is a RIOK2 inhibitor with anticancer activity. RIOK2 can highly selectively inhibit the growth of ERG-positive cancer cells with IC50s of 30-400 nM against cell lines. RIOK2 also causes cell cycle arrest and apoptosis in glioblastoma via induction of Skp2 and Skp2-p27/p21-Cyclin E/CDK2-pRb signaling .
    NSC139021
  • HY-15166
    (E/Z)-Zotiraciclib
    Maximum Cited Publications
    6 Publications Verification

    (E/Z)-TG02; (E/Z)-SB1317

    CDK JAK FLT3 Cancer
    (E/Z)-Zotiraciclib ((E/Z)-TG02) is a potent inhibitor of CDK2, JAK2 and FLT3 with IC50s of 13, 73 and 56 nM, respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer .
    (E/Z)-Zotiraciclib
  • HY-122620

    Hetrombopag (tautomerism); SHR-8735 (tautomerism)

    Thrombopoietin Receptor STAT PI3K ERK Apoptosis CDK Cardiovascular Disease Inflammation/Immunology
    Rafutrombopag (tautomerism) (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR‐expressing cells, including 32D‐ MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
    Rafutrombopag (tautomerism)
  • HY-15166A
    (E/Z)-Zotiraciclib hydrochloride
    Maximum Cited Publications
    6 Publications Verification

    (E/Z)-TG02 hydrochloride; (E/Z)-SB1317 hydrochloride

    CDK JAK FLT3 Cancer
    (E/Z)-Zotiraciclib ((E/Z)-TG02) is an orally active inhibitor of CDK2, JAK2 and FLT3 with IC50s of 13, 73 and 56 nM, respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer .
    (E/Z)-Zotiraciclib hydrochloride
  • HY-136726

    CINK4

    CDK Cancer
    GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer .
    CGP-82996
  • HY-145589

    Hetrombopag; SHR-8735

    Thrombopoietin Receptor STAT PI3K ERK Apoptosis CDK Cardiovascular Disease Inflammation/Immunology Cancer
    Rafutrombopag (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
    Rafutrombopag
  • HY-162318A
    MYC degrader 1 TFA
    1 Publications Verification

    Molecular Glues c-Myc Cancer
    MYC degrader 1 TFA (compound A80.2HCl) is an orally available MYC molecular glues degrader with anti-tumor activity. MYC degrader 1 TFA restores pRB1 protein activity and re-establishes sensitivity of MYC overexpressing cancer cells to CDK4/6 inhibitors .
    MYC degrader 1 TFA
  • HY-201330

    RGT-419B

    CDK Cancer
    GDC-4198 (RGT-419B) is an orally active CDK4/2 inhibitor with desired degrees of selectivity against kinases such as CDK6, CDK9 and GSK3β. GDC-4198 inhibits the activity of cyclin-CDK complexes, blocks phosphorylation of the retinoblastoma protein (pRb), arresting the cell cycle transition from G1 to S phase. GDC-4198 is promising for research of cancers, such as breast cancer (especially hormone receptor-positive, HER2-negative type), lung cancer, and colorectal cancer .
    GDC-4198
  • HY-RS11052

    Small Interfering RNA (siRNA) Others

    PRB2 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PRB2 Human Pre-designed siRNA Set A
    PRB2 Human Pre-designed siRNA Set A
  • HY-RS11051

    Small Interfering RNA (siRNA) Others

    PRB1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PRB1 Human Pre-designed siRNA Set A
    PRB1 Human Pre-designed siRNA Set A
  • HY-RS11053

    Small Interfering RNA (siRNA) Others

    PRB3 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PRB3 Human Pre-designed siRNA Set A
    PRB3 Human Pre-designed siRNA Set A
  • HY-RS11054

    Small Interfering RNA (siRNA) Others

    PRB4 Human Pre-designed siRNA Set A contains three designed siRNAs for PRB4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PRB4 Human Pre-designed siRNA Set A
    PRB4 Human Pre-designed siRNA Set A
  • HY-RS10397

    Small Interfering RNA (siRNA) Others

    Pgr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pgr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pgr Mouse Pre-designed siRNA Set A
    Pgr Mouse Pre-designed siRNA Set A
  • HY-147220

    Dex-Ox

    Progesterone Receptor Endocrinology
    Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms .
    Dexamethasone oxetanone
  • HY-RS11713

    Small Interfering RNA (siRNA) Others

    RB1 Human Pre-designed siRNA Set A contains three designed siRNAs for RB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RB1 Human Pre-designed siRNA Set A
    RB1 Human Pre-designed siRNA Set A
  • HY-16290

    ZK 230211; BAY86 5044

    Progesterone Receptor Endocrinology
    Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC50 of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect .
    Lonaprisan
  • HY-173007

    Akt PI3K Anaplastic lymphoma kinase (ALK) CDK Apoptosis Mitochondrial Metabolism Cancer
    ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC50 of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids .
    ALK/PI3K/AKT-IN-1
  • HY-186132

    PROTACs CDK Cancer
    PROTAC CDK2-pRb degrader-1 is an orally active PROTAC-class degrader of CDK2. PROTAC CDK2-pRb degrader-1 effectively inhibits the phosphorylation of retinoblastoma protein (Rb) at serine residues 807/811 by inducing ubiquitination and proteasomal degradation of CDK2. PROTAC CDK2-pRb degrader-1 exhibits significant activity against human cells (with EC50 values of 12 nM and 125 nM, respectively). In xenograft models, PROTAC CDK2-pRb degrader-1 effectively inhibits tumor growth and induces tumor stasis, making it suitable for research related to CCNE1-amplified cancers (such as ovarian cancer, gastric cancer, and breast cancer) .
    PROTAC CDK2-pRb degrader-1
  • HY-185164

    CDK Cancer
    Anticancer agent 302 (Example 1) is an anticancer agent. Anticancer agent 302 has a DC50 value of 199 nM for Cyclin E1 and an IC50 value of 133 nM for pRB. Anticancer agent 302 can be used for tumor research .
    Anticancer agent 302
  • HY-RS16852

    Small Interfering RNA (siRNA) Others

    Rb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Rb1 Mouse Pre-designed siRNA Set A
    Rb1 Mouse Pre-designed siRNA Set A
  • HY-182447

    DL111-IT

    CDK Apoptosis Endocrinology Cancer
    Contragestazol (DL111-IT) is a non-hormonal antifertility agent. Contragestazol reduces the expression of Cyclin D1 and CDK4, increases the expression of total retinoblastoma protein (pRb), and decreases the level of hyperphosphorylated pRb. Contragestazol induces G0/G1 phase cell cycle arrest. Contragestazol inhibits embryonic development by inducing luteal cell apoptosis and reducing intrauterine polyamine levels. Contragestazol exhibits antitumor activity against prostate cancer, S180 tumor and H22 tumor. Contragestazol shows extremely potent activity in terminating early pregnancy in animals .
    Contragestazol

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