1147-56-4
1147-56-4
Chemical Structure
NSC139021
Synonym(s): ERGi-USU
- CAS No.: 1147-56-4
- Formula:C13H9N3OS
- Molecular Weight:255.30
IUPAC Name: (E)-1-(thiazol-2-yldiazenyl)naphthalen-2-ol
InChIKey: IOMXCGDXEUDZAK-FOCLMDBBSA-N
SMILES: OC1=C(/N=N/C2=NC=CS2)C3=CC=CC=C3C=C1
Biological Activity: NSC139021 (ERGi-USU) is a RIOK2 inhibitor with anticancer activity. RIOK2 can highly selectively inhibit the growth of ERG-positive cancer cells with IC50s of 30-400 nM against cell lines. RIOK2 also causes cell cycle arrest and apoptosis in glioblastoma via induction of Skp2 and Skp2-p27/p21-Cyclin E/CDK2-pRb signaling[1][2].
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NSC139021 | 99.77% | NSC139021 (ERGi-USU) is a RIOK2 inhibitor with anticancer activity. RIOK2 can highly selectively inhibit the growth of ERG-positive cancer cells with IC50s of 30-400 nM against cell lines. RIOK2 also causes cell cycle arrest and apoptosis in glioblastoma via induction of Skp2 and Skp2-p27/p21-Cyclin E/CDK2-pRb signaling. | ||||||||||||||||||||
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References
- [1]. Yu M, et al. RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis. Biomedicines. 2021 Sep 17;9(9):1244. [Content Brief]
- [2]. Mohamed AA, et al. Identification of a small molecule that selectively inhibits ERG-positive cancer cell growth. Cancer Res. 2018 Apr 30. pii: canres.2949.2017. [Content Brief]
Keywords
