359886-84-3
Chemical Structure
CGP-82996
Synonym(s): CINK4
- CAS No.: 359886-84-3
- Formula:C27H32N6O
- Molecular Weight:456.58
IUPAC Name: (1r,4r)-4-((2-((1-benzyl-1H-indol-5-yl)amino)-6-(ethylamino)pyrimidin-4-yl)amino)cyclohexan-1-ol
InChIKey: YVXCDLCJCIDFHE-AFARHQOCSA-N
SMILES: O[C@H]1CC[C@H](NC2=NC(NC3=CC4=C(N(CC5=CC=CC=C5)C=C4)C=C3)=NC(NCC)=C2)CC1
Biological Activity: GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer[1][2].
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CGP-82996 | 98.12% | GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer. | ||||||||||||||||||||
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- [1]. Soni R, et al. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. J Natl Cancer Inst. 2001 Mar 21;93(6):436-46. [Content Brief]
- [2]. Zhang XH, et al. A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS. Cancer Biol Ther. 2013;14(7):597-605. [Content Brief]
Keywords
