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Pathways Recommended: Metabolic Enzyme/Protease
Results for "

Protease

" in MedChemExpress (MCE) Product Catalog:

1279

Inhibitors & Agonists

8

Screening Libraries

24

Fluorescent Dyes

27

Biochemical Assay Reagents

200

Peptides

6

MCE Kits

11

Inhibitory Antibodies

131

Natural
Products

225

Recombinant Proteins

39

Isotope-Labeled Compounds

100

Antibodies

3

Click Chemistry

11

Oligonucleotides

2

GMP Molecules

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P0018
    Pepstatin
    Maximum Cited Publications
    59 Publications Verification

    Pepstatin A

    		 HIV Protease Autophagy Infection Inflammation/Immunology
    Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .
    Pepstatin
  • HY-18234A
    Leupeptin hemisulfate
    Maximum Cited Publications
    61 Publications Verification

    		 Cathepsin Ser/Thr Protease Virus Protease Infection Inflammation/Immunology
    Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .
    Leupeptin hemisulfate
  • HY-108717
    Proteinase K
    20+ Cited Publications

    Protease K

    		 Ser/Thr Protease Others
    Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection .
    Proteinase K
  • HY-131577
    Neutral protease, Paenibacillus polymyxa
    5 Publications Verification

    Dispase II, Dispase

    		 Endogenous Metabolite Metabolic Disease
    Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum .
    Neutral protease, Paenibacillus polymyxa
  • HY-131577A
    Neutral protease I

    Dispase I

    		 Collagen Others
    Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin .
    Neutral protease I
  • HY-P1308
    SLIGRL-NH2
    2 Publications Verification

    Protease-Activated Receptor-2 Activating Peptide

    		 Protease Activated Receptor (PAR) Inflammation/Immunology
    SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2) .
    SLIGRL-NH2
  • HY-E70563
    Endoproteinase Lys-N (MS grade)

    		Biochemical Assay Reagents Others
    Endoproteinase Lys-N (MS grade) is a protease that specifically hydrolyzes the N-terminal peptide bond of lysine fragments .
    Endoproteinase Lys-N (MS grade)
  • HY-E70200
    Recombinant Kex2 protease

    		Ser/Thr Protease Others
    Recombinant Kex2 protease is a membrane-bound, Ca 2+-dependent serine protease. Recombinant Kex2 protease specifically recognize and cleave the carboxyl-terminal peptide bonds of dibasic amino acids .
    Recombinant Kex2 protease
  • HY-P0283
    Protease-Activated Receptor-2, amide
    2 Publications Verification

    		 Protease Activated Receptor (PAR) Cancer
    Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide.
    Protease-Activated Receptor-2, amide
  • HY-108717B
    Proteinase K (NGS grade)

    Protease K (NGS grade)

    		 Ser/Thr Protease Others
    Proteinase K (Protease K) (NGS grade) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K (NGS grade) is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K (NGS grade) can be use for promoting methods of viral nucleic acid extraction, and detection. This product is NGS grade, no Nickase residue, and nucleic acid residue ≤5 pg/mg .
    Proteinase K (NGS grade)
  • HY-17541
    Cysteine Protease inhibitor
    3 Publications Verification

    		 Cathepsin Others
    Cysteine Protease inhibitor is a cysteine protease inhibitor. Cysteine Protease inhibitor can be used in immunoblotting experiments of cells or tissues .
    Cysteine Protease inhibitor
  • HY-18234
    Leupeptin

    		Ser/Thr Protease Virus Protease Cathepsin Infection Inflammation/Immunology
    Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits M pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .
    Leupeptin
  • HY-P2973
    Aspergillopepsin I

    Aspergillus acid Protease

    		 Proteasome Others
    Aspergillopepsin I (Aspergillus acid protease) is a metal-containing aspartic protease that catalyzes the hydrolysis of peptide bonds in soybean 7S globulin, soybean 11S globulin and various proteins, with broad specificity. Aspergillopepsin I is intended for use in wine production, where it hydrolyzes haze-forming proteins into small peptides to prevent turbidity during storage. Aspergillopepsin I can be used in studies related to soybean protein hydrolysis and wine production .
    Aspergillopepsin I
  • HY-E70370
    hrv 3c Protease

    		Virus Protease Others
    hrv 3c Protease is a protease originated from human rhinoviruses. hrv 3c Protease recognizes the sequence LEVLFQGP and cleaves precisely between the Q and GP residues. hrv 3c Protease can be used to remove additional tags from the target proteins .
    hrv 3c Protease
  • HY-P3949
    Fluorescent Substrate for Glu-Specific Proteases

    		Fluorescent Dye Others
    Fluorescent Substrate for Glu-Specific Proteases is a V8 protease-Specific chromogenic substrate .
    Fluorescent Substrate for Glu-Specific Proteases
  • HY-E70574
    Trypsin/Lys-C complex protease (MS grade)

    		Biochemical Assay Reagents Others
    Trypsin/Lys-C complex protease (MS grade) combines Trypsin and Lys-C, two recombinant proteases, to achieve efficient peptide bond hydrolysis. Trypsin specifically cleaves the C-terminal peptide bonds of arginine (R) and lysine (K), while Lys-C specifically cleaves the C-terminal peptide bonds of lysine (K). This combination overcomes issues such as the slower digestion rate of lysine and arginine by rTrypsin, PTM changes on lysine, or hydrophobic C-termini (such as proline) that can lead to missed cleavage. Trypsin/Lys-C complex protease (MS grade) can be used to process complex protein samples that are difficult to enzymatically digest. Trypsin/Lys-C complex protease (MS grade) can be used for protein characterization, single-cell proteomics and large cohort proteomics studies.
    Trypsin/Lys-C complex protease (MS grade)
  • HY-P2518
    Protease-Activated Receptor-1, PAR-1 Agonist

    		Protease Activated Receptor (PAR) Inflammation/Immunology
    Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor .
    Protease-Activated Receptor-1, PAR-1 Agonist
  • HY-P2942
    Chymotrypsinogen

    		Ser/Thr Protease Inflammation/Immunology
    Chymotrypsinogen is an inactive precursor of Chymotrypsin (HY-108910). Chymotrypsin is a serine protease produced by the pancreas .
    Chymotrypsinogen
  • HY-E70528
    HRV-3C protease fuses with GST

    		Biochemical Assay Reagents Others
    HRV-3C protease fuses with GST is a recombinant protease that combines human rhinovirus (HRV) type 14 3C protease and a GST-tag. HRV-3C protease fuses with GST can specifically recognize the short peptide Leu-Glu-Val-Leu-Phe-Gln-Gly-Pro at 4°C and cleave between Gln and Gly amino acids .
    HRV-3C protease fuses with GST
  • HY-P0297
    Protease-Activated Receptor-4

    		Protease Activated Receptor (PAR) Others
    Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).
    Protease-Activated Receptor-4
  • HY-17541A
    Cysteine Protease inhibitor hydrochloride
    3 Publications Verification

    		 Cholinesterase (ChE) Cathepsin Neurological Disease
    Cysteine Protease inhibitor hydrochloride, an inhibitor of Cysteine Protease, binds to acetylcholinesterase (AChE). Cysteine Protease inhibitor hydrochloride is applicable to the research of Alzheimer's disease .
    Cysteine Protease inhibitor hydrochloride
  • HY-E70364
    IgdE protease

    		Biochemical Assay Reagents Inflammation/Immunology
    IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage .
    IgdE protease
  • HY-P2935
    Glutamic acid protease

    		Endogenous Metabolite Others
    Glutamic acid protease is a type of proteolytic enzyme containing glutamic acid residues, which mainly exists in fungi. Glutamic acid protease exerts its catalytic function through a glutamate-glutamine dyad .
    Glutamic acid protease
  • HY-E70372
    SUMO Protease

    		Biochemical Assay Reagents Others
    SUMO Protease is highly specific for proteins containing small ubiquitin-like modifier (SUMO) tags. SUMO Protease can be used to regulates the proteins splicing, controlls protein structure and function in vitro .
    SUMO Protease
  • HY-P0018A
    Pepstatin Trifluoroacetate
    Maximum Cited Publications
    59 Publications Verification

    Pepstatin A Trifluoroacetate

    		 HIV Protease Autophagy Infection Inflammation/Immunology
    Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .
    Pepstatin Trifluoroacetate
  • HY-P0018B
    Pepstatin Ammonium
    Maximum Cited Publications
    59 Publications Verification

    Pepstatin A Ammonium

    		 HIV Protease Autophagy Infection Inflammation/Immunology
    Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .
    Pepstatin Ammonium
  • HY-108882D
    Recombinant DNase I Protease & RNase free, animal free

    		DNA/RNA Synthesis Others
    Recombinant DNase I (Protease & RNase free, animal free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I (Protease & RNase free, animal free) is essential for limiting inflammatory responses and maintaining homeostasis. This product is recombinant bovine pancreatic DNase I, purified by chromatography, free of animal-derived components, RNase and protease, and contains glycine as a stabilizer .
    Recombinant DNase I Protease & RNase free, animal free
  • HY-129046E
    RNase A DNase & Protease Free, Recombinant

    Ribonuclease A DNase & Protease Free, Recombinant

    		 Endonuclease DNA/RNA Synthesis Endocrinology Cancer
    RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability. RNase A (DNase & Protease Free), Recombinant is recombinant RNase A, which does not contain DNase and protease .
    RNase A DNase & Protease Free, Recombinant
  • HY-P3934
    HIV Protease Substrate I

    		HIV Protease Infection
    HIV Protease Substrate I is a chromogenic substrate of HIV-1 protease. HIV Protease Substrate I has the cleavage site of HIV protease .
    HIV Protease Substrate I
  • HY-108285
    (Rac)-Telmesteine

    		Ser/Thr Protease Inflammation/Immunology
    (Rac)-Telmesteine is a protease inhibitor and is thus a suitable enzyme stabilizer extracted from patent WO 2017220302 A1, compound II-1. (Rac)-Telmesteine can be used as an enzyme stabilizer in protease-containing detergents and cleaning agents .
    (Rac)-Telmesteine
  • HY-I0179
    ITMN 4077

    		HCV Protease Infection
    ITMN 4077 is a macrocyclic inhibitor against Hepatitis C Virus (HCV) NS3 protease (EC50: 2131 nM) .
    ITMN 4077
  • HY-E70531
    Collagenase/Neutral protease 2 (animal free)

    		Biochemical Assay Reagents Others
    Collagenase/Neutral protease 2 (animal free) is an animal-free mixture of collagenase and neutral protease that can be used for stem cell and other primary cell isolation and bioprocessing applications without the introduction of potential animal-borne pathogens. It has higher casein activity than Collagenase/Neutral Protease 1 (animal free).
    Collagenase/Neutral protease 2 (animal free)
  • HY-E70365
    IdeS protease

    		Biochemical Assay Reagents Inflammation/Immunology
    IdeS protease is an IgG-specific endopeptidase, which is highly specific for the lower hinge region of IgG. IdeS protease represses innate immune responses to promote streptococcal survival in an inflammatory environment .
    IdeS protease
  • HY-E70420
    SpeB cysteine protease

    		Bacterial Inflammation/Immunology
    SpeB cysteine protease is a potent modifier of immunologically important host and bacterial proteins. SpeB cysteine protease degrades streptolysin O (SLO) in extracellular vesicles .
    SpeB cysteine protease
  • HY-144688
    HIV-1 protease-IN-1

    		HIV Infection
    HIV-1 protease-IN-1 (Compound 1e) is a potent inhibitor of HIV-1 protease with an IC50 of 90 pM. HIV-1 protease-IN-1 demonstrates antiviral activity with EC50 value of 89 nM against B-HIV. HIV-1 protease-IN-1 exhibits activity with EC50 value of 13.59 nM against C-HIV strain ZM246. HIV-1 protease-IN-1 shows remarkable activity with EC50 value of 8.23 nM against C-HIV strain Indie [1].
    HIV-1 protease-IN-1
  • HY-147650
    HIV-1 protease-IN-5

    		HIV Protease Infection
    HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC50 of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants .
    HIV-1 protease-IN-5
  • HY-174998
    HIV-1 protease-IN-15

    		HIV HIV Protease Infection
    HIV-1 protease-IN-15 (Compound 27) is an orally active and selective inhibitor targeting HIV-1 protease with a pIC50 value of 9.347. HIV-1 protease-IN-15 inhibits HIV protein maturation, blocks viral replication. HIV-1 protease-IN-15 is promising for research of HIV-1 infection .
    HIV-1 protease-IN-15
  • HY-P3980
    HIV-1, HIV-2 Protease Substrate

    		HIV Protease Infection
    HIV-1, HIV-2 Protease Substrate is the substrate of HIV-1, HIV-2 protease. And there are 4 residues for conservative substitutions of the substrate binding residues of HIV-1 and HIV-2 protease .
    HIV-1, HIV-2 Protease Substrate
  • HY-175279
    CHIKV nsP2 protease-IN-3

    		Virus Protease Infection
    CHIKV nsP2 protease-IN-3 (Compound 5) is an irreversible covalent inhibitor targeting the nonstructural protein 2 (nsP2) cysteine protease of chikungunya virus (CHIKV) (IC50=0.5 μM). CHIKV nsP2 protease-IN-3 inhibits viral RNA replication. CHIKV nsP2 protease-IN-3 is promising for research of alphaviruses .
    CHIKV nsP2 protease-IN-3
  • HY-150549
    HIV-1 protease-IN-6

    		HIV Protease HIV Infection Inflammation/Immunology
    HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC50 of 21 pM and a Ki of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus .
    HIV-1 protease-IN-6
  • HY-173554
    MPXV I7L protease-IN-1

    		HSV Infection
    MPXV I7L protease-IN-1 (compound 11) is a Monkeypox virus I7L protease inhibitor with the IC50 of 69 nM .
    MPXV I7L protease-IN-1
  • HY-18234AR
    Leupeptin hemisulfate (Standard)

    		Reference Standards Cathepsin Ser/Thr Protease Virus Protease Infection Inflammation/Immunology
    Leupeptin (hemisulfate) (Standard) is the analytical standard of Leupeptin (hemisulfate). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].
    Leupeptin hemisulfate (Standard)
  • HY-E70586
    Elastase (high purity)

    		Ser/Thr Protease Others
    Elastase (high purity) is a serine protease that hydrolyzes proteins and peptides.
    Elastase (high purity)
  • HY-126973
    BI-1230

    		HCV Protease Infection
    BI-1230, a chemical probe, is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity .
    BI-1230
  • HY-E70331
    Acid Stable Protease

    		Endogenous Metabolite Others
    Acid Stable Protease is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
    Acid Stable Protease
  • HY-E70354
    Protease for flavors

    		Endogenous Metabolite Others
    Protease for flavors is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
    Protease for flavors
  • HY-P4243
    Dansyl-Glu-Gly-Arg-Chloromethylketone

    		Ser/Thr Protease Others
    Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone inhibits activated porcine factor IX .
    Dansyl-Glu-Gly-Arg-Chloromethylketone
  • HY-P4018
    HIV Protease Substrate IV

    		HIV Protease Infection
    HIV Protease Substrate IV is a substrate of HIV protease. HIV Protease Substrate IV can be used to measure the activity of HIV (human immunodeficiency virus) -1 protease .
    HIV Protease Substrate IV
  • HY-155691
    HIV-1 protease-IN-12

    		HIV Protease Infection
    HIV-1 protease-IN-12 (compound 35b) is a HIV-1 protease inhibitor with an IC50 of 0.51 nM. HIV-1 protease-IN-12 also inhibits drug-resistant variant .
    HIV-1 protease-IN-12
  • HY-P2344
    HIV Protease Substrate 1

    		HIV Protease Infection
    HIV Protease Substrate 1, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease .
    HIV Protease Substrate 1

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