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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
RNA-binding domain
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "RNA-binding domain" in MCE Product Catalog:
Cat. No.: HY-175238
CAS No.: 1309288-83-2
Target:
Research Areas:
KI-DX-014 is a DDX21 inhibitor with high RNA-binding inhibitory activity (IC50 of 3.31 μM). KI-DX-014 targets DDX21’s intrinsically disordered C-terminal domain, inhibits DDX21-structured RNA interaction, modulates DDX21’s RNA-dependent ATPase activity, and disrupts DDX21 biomolecular condensate formation. KI-DX-014 attenuates in vitro P-TEFb release from the 7SK snRNP complex, suppresses P-TEFb-dependent RNA polymerase II CTD phosphorylation, and induces developmental defects in zebrafish embryos. KI-DX-014 acts as a chemical probe for dissecting DDX21 functions in normal physiology and disease states. KI-DX-014 can be used for cancers and neurodegenerative disorders research .
Cat. No.: HY-P5960
Synonyms: PTBP1 α3-helix derived peptide P6 TFA
Target:
Research Areas:
Cat. No.: HY-181846
CAS No.: 1065567-62-5
Target:
Research Areas:
nTRD22 is an RNA-binding allosteric modulator targeting TDP-43. nTRD22 binds to the N-terminal domain of TDP-43, thereby allosterically regulating the RNA-binding domain of TDP-43 and reducing its RNA-binding ability. nTRD22 decreases the TDP-43 protein level in primary motor neurons. nTRD22 alleviates motor dysfunction in amyotrophic lateral sclerosis models. nTRD22 is applicable to related research on amyotrophic lateral sclerosis .
Cat. No.: HY-155237
LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD). LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC50: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC50: 6.4 μM) .
Cat. No.: HY-P703268
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: QKI; Quaking Homolog, KH domain RNA binding; QKI, KH domain Containing RNA binding; QKI/LOC100132735 Fusion; QK3; RNA binding Protein HQK; KH domain-Containing RNA-binding Protein QKI; Protein Quaking; HqkI; QK1; Hqk; HKQ; Homolog Of Mouse Quaking QKI (KH
Cat. No.: HY-187350
Research Areas:
LRPPRC-IN-1 is a LRPPRC inhibitor. LRPPRC-IN-1 exerts dual effects of inhibiting LRPPRC activity and inducing its degradation by binding to the RNA-binding domain of LRPPRC. LRPPRC-IN-1 downregulates the expression of mitochondrial OXPHOS complex subunits and ATP synthase, inhibits oxidative phosphorylation, reduces ATP production, suppresses the proliferation and colony formation of various cancer cells, and inhibits tumor growth in vivo. LRPPRC-IN-1 can be used in studies related to lung cancer, pancreatic cancer, breast cancer, esophageal cancer, colorectal cancer, lymphoma, melanoma, cervical cancer, ovarian cancer, and prostate cancer .
Cat. No.: HY-P704522
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LIN28A; Zinc Finger CCHC domain-Containing Protein 1; Prev. LIN28; FLJ12457; ZCCHC1; Lin-28A; CSDD1; Zinc Finger, CCHC domain Containing 1; Lin-28 Homolog A; Lin-28 Homolog (C. Elegans); LIN-28; RNA-binding Protein LIN-28; Lin-28 RNA binding Posttranscrip
Cat. No.: HY-P703348
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SUGP1; F23858; Prev. SF4; RNA-binding Protein RBP; Splicing Factor 4; DKFZp434E2216; SURP And G-Patch domain-Containing Protein 1; CDNA FLJ57089, Highly Similar To Splicing Factor 4; SURP And G-Patch domain Containing 1; RBP
Cat. No.: HY-P87046
Synonyms: DKFZp586I0923 antibody; HKQ antibody; Homolog of mouse quaking QKI KH domain RNA binding protein antibody; Hqk antibody; HQK1 antibody; HqkI antibody; OTTHUMP00000017581 antibody; OTTHUMP00000017582 antibody; OTTHUMP00000017583 antibody; Protein quaking antibody; DKFZp586I0923 antibody; HKQ antibody; Homolog of mouse quaking QKI KH domain RNA binding protein antibody; Hqk antibody; HQK1 antibody; HqkI antibody; OTTHUMP00000017581 antibody; OTTHUMP00000017582 antibody; OTTHUMP00000017583 antibody; Protein quaking antibody; QK antibody; QK1 antibody; QK3 antibody; QKI antibody; QKI_HUMAN antibody; QKI1 antibody; Quaking homolog antibody; Quaking homolog KH domain RNA binding antibody; Quaking homolog KH domain RNA binding mouse antibody; Quaking isoform 1 antibody; Quaking protein antibody; RNA binding protein HQK antibody;
Cat. No.: HY-P702576
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: YTHDF2; YTH N6‑Methyladenosine RNA binding Protein F2; HGRG8; NY‑REN‑2; CAHL; YTH N(6)‑Methyladenosine RNA binding Protein 2; YTH N6‑Methyladenosine RNA binding Protein 2; YTH domain‑Containing Family Protein 2; High‑Glucose‑Regulated Protein 8; Renal Car
Cat. No.: HY-P87045
Synonyms: DKFZp586I0923 antibody; HKQ antibody; Homolog of mouse quaking QKI KH domain RNA binding protein antibody; Hqk antibody; HQK1 antibody; HqkI antibody; OTTHUMP00000017581 antibody; OTTHUMP00000017582 antibody; OTTHUMP00000017583 antibody; Protein quaking antibody; DKFZp586I0923 antibody; HKQ antibody; Homolog of mouse quaking QKI KH domain RNA binding protein antibody; Hqk antibody; HQK1 antibody; HqkI antibody; OTTHUMP00000017581 antibody; OTTHUMP00000017582 antibody; OTTHUMP00000017583 antibody; Protein quaking antibody; QK antibody; QK1 antibody; QK3 antibody; QKI antibody; QKI_HUMAN antibody; QKI1 antibody; Quaking homolog antibody; Quaking homolog KH domain RNA binding antibody; Quaking homolog KH domain RNA binding mouse antibody; Quaking isoform 1 antibody; Quaking protein antibody; RNA binding protein HQK antibody; QKI-6
Cat. No.: HY-P704032
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSDE1; N-Ras Upstream Gene Protein; Cold Shock domain Containing E1; Upstream Of NRAS; D1S155E; NRAS-Related; UNR; Protein UNR; Cold Shock domain-Containing Protein E1; KIAA0885; Cold Shock domain Containing E1, RNA binding; NRU
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
