QKI-6 Antibody (YA6738)
(Synonyms: DKFZp586I0923 antibody; HKQ antibody; Homolog of mouse quaking QKI KH domain RNA binding protein antibody; Hqk antibody; HQK1 antibody; HqkI antibody; OTTHUMP00000017581 antibody; OTTHUMP00000017582 antibody; OTTHUMP00000017583 antibody; Protein quaking antibody; DKFZp586I0923 antibody; HKQ antibody; Homolog of mouse quaking QKI KH domain RNA binding protein antibody; Hqk antibody; HQK1 antibody; HqkI antibody; OTTHUMP00000017581 antibody; OTTHUMP00000017582 antibody; OTTHUMP00000017583 antibody; Protein quaking antibody; QK antibody; QK1 antibody; QK3 antibody; QKI antibody; QKI_HUMAN antibody; QKI1 antibody; Quaking homolog antibody; Quaking homolog KH domain RNA binding antibody; Quaking homolog KH domain RNA binding mouse antibody; Quaking isoform 1 antibody; Quaking protein antibody; RNA binding protein HQK antibody; QKI-6 )QKI-6 Antibody (YA6738) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to QKI-6.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, IHC-F
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Reactivity :
Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:2000 | 1:500 |
Product Details
QKI-6 Antibody (YA6738) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to QKI-6.
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Host Mouse
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Clonality Recombinant,Monoclonal
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Species ReactivityMouse, Rat Predicted Reactivity: Cynomolgus monkey
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 35 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 35 kDa
Synthetic peptide within human QKI-6 aa 281-319 / 319.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
QKI-6 is a Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation. Acts as a translational repressor for HNRNPA1 and GLI1. Translation inhibition of HNRNPA1 during oligodendrocyte differentiation prevents inclusion of exon 12 in MAG pre-mRNA splicing. Involved in astrocyte differentiation by regulating translation of target mRNAs[1].
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Subcellular Localization
Cytoplasm, cytosol,Nucleus
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Isoforms & Post-Translational Modification
Q96PU8-9 has 6 isomers: Q96PU8-1: 37671 Da (predicted); Q96PU8-3: 36926 Da (predicted); Q96PU8-5: 35233 Da (predicted); Q96PU8-6: 35978 Da (predicted); Q96PU8-8: 35248 Da (predicted); Q96PU8-9: 35131 Da (predicted).
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Subunit
Interacts with G3BP1; directing N(7)-methylguanine (m7G)-containing mRNAs to stress granules to suppress mRNA translation
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SwissProt ID
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Synonyms
DKFZp586I0923 antibody; HKQ antibody; Homolog of mouse quaking QKI KH domain RNA binding protein antibody; Hqk antibody; HQK1 antibody; HqkI antibody; OTTHUMP00000017581 antibody; OTTHUMP00000017582 antibody; OTTHUMP00000017583 antibody; Protein quaking antibody; DKFZp586I0923 antibody; HKQ antibody; Homolog of mouse quaking QKI KH domain RNA binding protein antibody; Hqk antibody; HQK1 antibody; HqkI antibody; OTTHUMP00000017581 antibody; OTTHUMP00000017582 antibody; OTTHUMP00000017583 antibody; Protein quaking antibody; QK antibody; QK1 antibody; QK3 antibody; QKI antibody; QKI_HUMAN antibody; QKI1 antibody; Quaking homolog antibody; Quaking homolog KH domain RNA binding antibody; Quaking homolog KH domain RNA binding mouse antibody; Quaking isoform 1 antibody; Quaking protein antibody; RNA binding protein HQK antibody; QKI-6
Documentation
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