1065567-62-5
Chemical Structure
nTRD22
- CAS No.: 1065567-62-5
- Formula:C19H22F3N3O4
- Molecular Weight:413.39
InChIKey: SOUBULALAAVDBB-UHFFFAOYSA-N
SMILES: O=C(C1=NOC(COC2=CC=CC(C(F)(F)F)=C2)=C1)NCCN3CCCC(C3)O
Biological Activity: nTRD22 is an RNA-binding allosteric modulator targeting TDP-43. nTRD22 binds to the N-terminal domain of TDP-43, thereby allosterically regulating the RNA-binding domain of TDP-43 and reducing its RNA-binding ability. nTRD22 decreases the TDP-43 protein level in primary motor neurons. nTRD22 alleviates motor dysfunction in amyotrophic lateral sclerosis models. nTRD22 is applicable to related research on amyotrophic lateral sclerosis[1].
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nTRD22 | 95.0% | nTRD22 is an RNA-binding allosteric modulator targeting TDP-43. nTRD22 binds to the N-terminal domain of TDP-43, thereby allosterically regulating the RNA-binding domain of TDP-43 and reducing its RNA-binding ability. nTRD22 decreases the TDP-43 protein level in primary motor neurons. nTRD22 alleviates motor dysfunction in amyotrophic lateral sclerosis models. nTRD22 is applicable to related research on amyotrophic lateral sclerosis. | ||||||||||||||||||||
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Keywords
