nTRD22
Based on 1 Customer Validation
nTRD22 is an RNA-binding allosteric modulator targeting TDP-43. nTRD22 binds to the N-terminal domain of TDP-43, thereby allosterically regulating the RNA-binding domain of TDP-43 and reducing its RNA-binding ability. nTRD22 decreases the TDP-43 protein level in primary motor neurons. nTRD22 alleviates motor dysfunction in amyotrophic lateral sclerosis models. nTRD22 is applicable to related research on amyotrophic lateral sclerosis.
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- Reinheit: 95.0%
- CAS. Nr.: 1065567-62-5
- Formel: C19H22F3N3O4
- Molecular Weight:413.39
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
nTRD22 (0.03 μM-1 mM) binds to full-length TDP-431-260 with an apparent Kd of 145 ± 3 μM and to the isolated N-terminal domain TDP-431-102 with an apparent Kd of 96 ± 36 μM[1].
nTRD22 inhibits TDP-431-260 binding to UG6 RNA with an IC50 of ~100 μM in an alpha assay[1].
nTRD22 (0.1-500 μM) inhibits TDP-431-260 binding to (UG)6 RNA with an IC50 of ~145 μM and achieves ~30% inhibition of the interaction in an SPR assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:GAL4-UAS bipartite expression system line (overexpressing human TDP-43 in motor neurons)[1]
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Dosage:50 μM
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Administration:incorporated into fly food; continuous exposure
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Result:Significantly improved motor performance, with a greater percentage of flies crossing the target climbing line over the 2-minute assay period compared to control groups.
Showed increased rescue effect in aged flies.
Chemical Information
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CAS. Nr. 1065567-62-5
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Appearance Solid
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Molecular Weight 413.39
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Formel C19H22F3N3O4
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Color White to light yellow
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SMILES
O=C(C1=NOC(COC2=CC=CC(C(F)(F)F)=C2)=C1)NCCN3CCCC(C3)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
nTRD22 Related Classifications
HY-181846 Related Classifications
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