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Results for "

Rutaceae

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

15

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N2081
    Skimmianine
    3 Publications Verification

    		 Cholinesterase (ChE) PI3K Akt NF-κB Neurological Disease Inflammation/Immunology Cancer
    Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca 2+ signaling and protein kinase C signaling .
    Skimmianine
  • HY-N0242
    Fraxinellone
    4 Publications Verification

    		 PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT Inflammation/Immunology Cancer
    Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1 .
    Fraxinellone
  • HY-N7029
    3',​4',​5',​5,​7-​Pentamethoxyflavone

    		Others Cancer
    3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic agents by inhibition of Nrf2 pathway .
    3',​4',​5',​5,​7-​Pentamethoxyflavone
  • HY-N4206
    Leptomerine

    		Cholinesterase (ChE) Neurological Disease
    Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC50 of 2.5 μM. Anticholinesterasic activity .
    Leptomerine
  • HY-N3406
    Lansiumarin C

    (+)-Lansiumarin C; 5-Demethoxymelicotriphyllin C

    		 Others Others
    Lansiumarin C, a lansiumarin, can be isolated from the branches of Clausena lansium (Rutaceae) .
    Lansiumarin C
  • HY-N11767
    Prenyletin

    		Others Others
    Prenyletin is a natural product, that can be isolated from the roots of Ptaeroxylon obliquum Radlk. (Rutaceae). Prenyletin shows anti-oxidative stress activity .
    Prenyletin
  • HY-N2081R
    Skimmianine (Standard)

    		Reference Standards Cholinesterase (ChE) PI3K Akt NF-κB Neurological Disease Inflammation/Immunology Cancer
    Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca 2+ signaling and protein kinase C signaling .
    Skimmianine (Standard)
  • HY-N3258
    Micromelin

    Micromelumin

    		 Others Others
    Micromelin is a coumarin from Micromelum minutum (Forst. f.) Seem (family Rutaceae) .
    Micromelin
  • HY-W995439
    Eduleine

    		Others Others
    Eduleine is an alkaloid found in Lunasia quercifolia in the Australian Rutaceae family. Eduleine is promising for research of antioxidants and enzyme inhibitors .
    Eduleine
  • HY-N0968
    1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone

    		Others Others
    1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone, as a colorless oil, is a quinolone alkaloid isolated from the fruit of Evodia rutaecarpa BENTHAM (Rutaceae) .
    1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone
  • HY-N0242R
    Fraxinellone (Standard)

    		Reference Standards PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT Inflammation/Immunology Cancer
    Fraxinellone (Standard) is the analytical standard of Fraxinellone. This product is intended for research and analytical applications. Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1 .
    Fraxinellone (Standard)
  • HY-W647293
    3-Methyl-9H-carbazol-2-ol

    		Drug Derivative Others
    3-Methyl-9H-carbazol-2-ol (compound 7) is a carbazole alkaloid that can be found in the twigs and leaves of Glycosmis montana Pierre (Rutaceae) .
    3-Methyl-9H-carbazol-2-ol
  • HY-N18094
    Evodiamide

    		Others
    Evodiamide is a new alkaloid found in the dried fruits of Evodia rutaecarpa (Rutaceae). Evodiamide acts as a proposed precursor in the biosynthesis of evodiamine .
    Evodiamide
  • HY-N16714
    Clausine K

    		Others Cancer
    Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC50 = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC50 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods .
    Clausine K
  • HY-N1788
    3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone

    		Others Others
    3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone (compound 7) is a flavonoid compound that can be used in research on natural product chemistry and the screening of potential activities of flavonoid compounds. 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone can be extracted from the dried leaves of Murraya paniculata (a plant of the Murraya genus in the Rutaceae family) .
    3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone

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