Search Result

Results for "

SHIP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (1) COX (2) Interleukin Related (1) MMP (2) NF-κB (2) NO Synthase (2) PANoptosis (1) Phosphatase (9) PI3K (1) Small Interfering RNA (siRNA) (2) TNF Receptor (1) Toll-like Receptor (TLR) (2) VEGFR (2)
By Research Areas:	Cancer (6) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Natural
Products

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19776

3α-Aminocholestane Maximum Cited Publications 6 Publications Verification	Phosphatase	Cancer
3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC₅₀ of ~2.5 μM.

HY-18686

AS1949490 1 Publications Verification	Phosphatase Akt	Metabolic Disease
AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC₅₀ values of 0.34, 0.62, 13, >50, >50, and >50 µM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes ^[1] .

HY-109011

Rosiptor 3 Publications Verification AQX-1125	Phosphatase	Cancer
Rosiptor (AQX-1125) is a selective and orally active phosphatase *SHIP1* activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro ^[1] .

HY-115620

AQX-016A	Phosphatase PI3K TNF Receptor	Inflammation/Immunology
AQX-016A is an orally active and potent *SHIP1* agonist. AQX-016A can activate recombinant *SHIP1* enzyme in vitro and stimulate *SHIP1* activity. AQX-016A also can inhibit the PI3K pathway and TNFa production, can be useful for various inflammatory diseases research ^[1] .

HY-N7700A

Guluronic acid sodium 1 Publications Verification G2013 sodium	VEGFR Toll-like Receptor (TLR) COX NO Synthase NF-κB MMP	Inflammation/Immunology Cancer
Guluronic acid (G2013) sodium is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid sodium up-regulates the expression of immunoregulatory genes *SHIP1* and *SOCS1*, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid sodium significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid sodium has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases ^[1] .

HY-N7700

Guluronic acid G2013	MMP COX VEGFR Toll-like Receptor (TLR) NF-κB NO Synthase	Inflammation/Immunology Cancer
Guluronic acid (G2013) is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid up-regulates the expression of immunoregulatory genes *SHIP1* and *SOCS1*, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases ^[1] .

HY-113817

SHIP1 activator 1	Phosphatase	Inflammation/Immunology
SHIP1 activator 1 is an SH3 domain-containing inositol 5-phosphatase regulator with SHIP1 activating activity. SHIP1 activator 1 retains its SHIA-1 activating ability by removing unnecessary functional groups. SHIP1 activator 1 is able to activate SHIP1 in vitro, inhibit Akt phosphorylation in MOLT-4 cells, and show dose-dependent activity in a mouse model of inflammation. SHIP1 activator 1 is an important chemical tool for evaluating the potential of SHIP1 activators as inhibitors of hematopoietic diseases involving abnormal PI3K cell signaling ^[1].

HY-136268

AQX-435	Phosphatase Apoptosis	Inflammation/Immunology
AQX-435 is a potent SHIP1 phosphatase activator. AQX-435 reduces PI3K activation downstream of the B-cell receptor (BCR) and induces apoptosis of malignant B cells, and reduces lymphoma growth ^[1] .

HY-RS21142

Inpp5d Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Inpp5d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Inpp5d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inpp5d Mouse Pre-designed siRNA Set A Inpp5d Mouse Pre-designed siRNA Set A

HY-117087

K103	Phosphatase PANoptosis	Cancer
K103 is an inhibitor discovered from the screen that is an analog of the serotonin antagonist benzazocine. K103 exhibited inhibition of SHIP homologues, labelling it a pan-SHIP1/2 inhibitor, but the molecule had no effect on another 5' inositol phosphatase, OCRL. In line with the "two PIPs hypothesis", the molecule exhibited significant anti-tumour effects against a variety of cell lines, particularly breast cancer cells. Additional studies with K103 revealed that inhibition of SHIP1/2 in multiple myeloma cells resulted in G2/M cell cycle arrest followed by extensive apoptosis via activation of the caspase cascade. K103 fits the commonly used small molecule agent property profile, but while this work was being conducted, it was discovered that K103 caused psychoactive effects in mice, which limited the utility of the molecule in vivo. Therefore, certain synthetic studies were conducted on this tryptamine to identify the features that needed to be present in the molecule to maintain pan-SHIP1/2 inhibition in order to design an inhibitor with favourable pharmacodynamic properties and an improved side effect profile.

HY-183593

SHIP1-IN-1	Phosphatase Akt Interleukin Related	Neurological Disease
SHIP1-IN-1 is an orally active, blood-brain barrier-permeable *SHIP1* ligand. SHIP1-IN-1 exhibits IC₅₀ values of 384 μM and 177 μM against human SHIP1, and an IC₅₀ value of 379 μM against murine SHIP1. SHIP1-IN-1 alters the binding state of SHIP1 to phosphatidylinositol membranes, and regulates phosphoinositide pools and phosphorylated AKT levels. SHIP1-IN-1 enhances the uptake of myelin/membrane fragments and amyloid proteins by microglia, alters gene expression and reduces *IL-1β* levels. SHIP1-IN-1 can be used in studies related to Alzheimer's disease ^[1] .

HY-109011A

Rosiptor acetate AQX-1125 acetate	Phosphatase	Cancer
Rosiptor (AQX-1125) acetate is a selective and orally active phosphatase *SHIP1* activator with anti-inflammatory effects. Rosiptor acetate (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro ^[1] .

HY-RS06829

INPP5D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
INPP5D Human Pre-designed siRNA Set A contains three designed siRNAs for INPP5D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

INPP5D Human Pre-designed siRNA Set A INPP5D Human Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7700A

Guluronic acid sodium 1 Publications Verification G2013 sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	VEGFR Toll-like Receptor (TLR) COX NO Synthase NF-κB MMP
Guluronic acid (G2013) sodium is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid sodium up-regulates the expression of immunoregulatory genes *SHIP1* and *SOCS1*, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid sodium significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid sodium has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases ^[1] .

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (1) ICC/IF (1) IP (2) WB (2) FC (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Phosphorylated (1) Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83087

	SHIP1 Antibody (YA2832) INPP5D; SHIP; SHIP1; Phosphatidylinositol 3; 4; 5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1	WB, IHC-P, IP, FC	Human
	SHIP1 Antibody (YA2832) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SHIP1.

HY-P83344

	*Phospho-SHIP1* (Tyr1020) Antibody (YA3089)** INPP5D; SHIP; SHIP1; Phosphatidylinositol 3; 4; 5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1	WB, ICC/IF, IP	Human
	Phospho-SHIP1 (Tyr1020) Antibody (YA3089) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-SHIP1 (Tyr1020).

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inpp5d Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Inpp5d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Inpp5d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

INPP5D Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
INPP5D Human Pre-designed siRNA Set A contains three designed siRNAs for INPP5D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks