849669-54-1
Chemical Structure
AQX-016A
- CAS No.: 849669-54-1
- Formula:C22H32O2
- Molecular Weight:328.49
IUPAC Name: (4aS,6aR,11aR,11bS)-4,4,6a,7,11b-pentamethyl-2,3,4,4a,5,6,6a,11,11a,11b-decahydro-1H-benzo[a]fluorene-9,10-diol
InChIKey: DTFQQAANPRPMBC-DEVSCXNHSA-N
SMILES: OC1=C(O)C2=C(C(C)=C1)[C@]3(C)CC[C@](C(C)(C)CCC4)([H])[C@@]4(C)[C@@]3([H])C2
Biological Activity: AQX-016A is an orally active and potent SHIP1 agonist. AQX-016A can activate recombinant SHIP1 enzyme in vitro and stimulate SHIP1 activity. AQX-016A also can inhibit the PI3K pathway and TNFa production, can be useful for various inflammatory diseases research[1][2].
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AQX-016A | 99.51% | AQX-016A is an orally active and potent SHIP1 agonist. AQX-016A can activate recombinant SHIP1 enzyme in vitro and stimulate SHIP1 activity. AQX-016A also can inhibit the PI3K pathway and TNFa production, can be useful for various inflammatory diseases research. | ||||||||||||||||||||
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- [1]. [1]Yau, Tien Yin. Novel strategies for antagonizing the phosphatidylinositol-3-kinase pathway in disease. University of British Columbia. 2010.
- [2]. Ong CJ, et al. Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood. 2007 Sep 15;110(6):1942-9. [Content Brief]
Keywords
