3 Results for "

TOP2α

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "TOP2α" in MCE Product Catalog:

Cat. No.: HY-122594
CAS No.: 1151668-24-4
Purity:  99%
Target:  

Topoisomerase

Research Areas:  

Cancer

BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity .
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Cat. No.: HY-N17442
CAS No.: 75410-53-6
Echinoside A is a saponin. Echinoside A can be isolated from sea cucumber. Echinoside A inhibits the catalytic activity of Top2α, reduces the noncovalent binding of Top2α to DNA. Echinoside A activates Caspase-3 and induces PARP cleavage. Echinoside A induces Apoptosis. Echinoside A has anticancer activity against prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Echinoside A exhibits antifungal activity against a variety of fungi, with a minimum growth inhibitory concentration range of 3.12 to 50.0 μg/mL, including potent activity against Aspergillus and Penicillium species [2] .
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Cat. No.: HY-P704742
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TOP2A; DNA TOPoisomerase 2-Alpha; Prev. TOP2; DNA TOPoisomerase II, 170 KD; TOP2alpha; DNA TOPoisomerase 2; TOPIIA; DNA Gyrase; TOPoisomerase (DNA) II Alpha 170kDa; TP2A; DNA TOPoisomerase II, Alpha Isozyme; DNA TOPoisomerase II Alpha; DNA TOPoisomerase (
Species:  
Human
Source:  
E. coli
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