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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
Tet1
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "Tet1" in MCE Product Catalog:
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26 Publications Verification
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Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription [1].
26
26 Publications Verification
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Research Areas:
Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription [1].
1
1 Cited Publications
Cat. No.: HY-402410
CAS No.: 1451750-73-4
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TETi76 is an orally active TET family inhibitor with IC50 values ??of 1.5, 9.4 and 8.8 μM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research [1].
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1 Cited Publications
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OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time [1] .
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1 Cited Publications
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NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5 [1].
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1 Cited Publications
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UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity [1].
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1 Cited Publications
Cat. No.: HY-160638
CAS No.: 73768-68-0
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NSC-311068 is TET1 inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1 [1].
Cat. No.: HY-P11094
CAS No.: 1048681-88-4
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Cat. No.: HY-P10998
CAS No.: 270919-17-0
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Cat. No.: HY-W018324
CAS No.: 1123-95-1
Synonyms: 5hmC
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Cat. No.: HY-RS23219
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Tet1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tet1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14384
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TET1 Human Pre-designed siRNA Set A contains three designed siRNAs for TET1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16779
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Tet1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tet1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W396714
CAS No.: 14047-56-4
Synonyms: Wormwood acid sodium
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Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research [1] .
Cat. No.: HY-W018324S
Synonyms: 5hmC-13C,d2
Cat. No.: HY-111558R
CAS No.: 2280037-51-4
Research Areas:
Bobcat339 (Standard) is the analytical standard of Bobcat339 (HY-111558). This product is intended for research and analytical applications. Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription [1].
Cat. No.: HY-P88065A
Synonyms: CXXC6; LCX
Cat. No.: HY-P702914
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Tet1; Methylcytosine Dioxygenase Tet1; Prev. CXXC6; CXXC Zinc Finger 6; LCX; Tet Oncogene 1; Leukemia-Associated Protein With A CXXC Domain; Ten-Eleven Translocation 1; BA119F7.1; Ten-Eleven Translocation-1; KIAA1676; CXXC Finger 6; Ten-Eleven Translocati
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Cat. No.: HY-111558AR
CAS No.: 2436747-44-1
Research Areas:
Bobcat339 hydrochloride (Standard) is the analytical standard of Bobcat339 (hydrochloride) (HY-111558A). This product is intended for research and analytical applications. Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
