1451750-73-4

TETi76 Chemical Structure
1451750-73-4

Chemical Structure

TETi76

  • CAS No.: 1451750-73-4
  • Formula:C10H16O5
  • Molecular Weight:216.23

InChIKey: KEGNSROWYBDVRX-UHFFFAOYSA-N

SMILES: O=C(OCC)C(O)CC(C(OCC)=O)=C

Biological Activity: TETi76 is an orally active TET family inhibitor with IC50 values ??of 1.5, 9.4 and 8.8 μM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research[1].

Cat. No. Product Name Purity Description Pricing
HY-402410 		TETi76 97.49% TETi76 is an orally active TET family inhibitor with IC50 values ??of 1.5, 9.4 and 8.8 μM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research.
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