mPEG-PLGA (21500-26500)

Cat. No.: HY-148775A Purity: 95.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MPEG-PLGA (21500-26500) is a biodegradable amphipathic polymeric nanocarrier of poly (lactic-co-glycolic acid)-block-poly (ethylene glycol) (PLGA-PEG-Mal) that allows covalent modification of functional molecules. MPEG-PLGA (21500-26500) modified with Angiopep-2 can cross the blood-brain barrier and exhibits targeting selectivity for glioblastoma cells. MPEG-PLGA (21500-26500) can capture tumor-derived protein antigens, and exerts immunomodulatory effects when conjugated with anti-OX40 antibody; when used in combination with A2-CL/Dbait nanoparticles and radiotherapy, it prolongs survival time and reduces tumor volume in glioblastoma mouse models. MPEG-PLGA (21500-26500) can be used for studies related to bacterial wound infections and glioblastoma.

For research use only. We do not sell to patients.

mPEG-PLGA (21500-26500) Chemical Structure

CAS No. : 743423-15-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Other Forms of mPEG-PLGA (21500-26500):

PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 40:60) In-stock
mPEG-PLGA In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description	MPEG-PLGA (21500-26500) is a biodegradable amphipathic polymeric nanocarrier of poly (lactic-co-glycolic acid)-block-poly (ethylene glycol) (PLGA-PEG-Mal) that allows covalent modification of functional molecules. MPEG-PLGA (21500-26500) modified with Angiopep-2 can cross the blood-brain barrier and exhibits targeting selectivity for glioblastoma cells. MPEG-PLGA (21500-26500) can capture tumor-derived protein antigens, and exerts immunomodulatory effects when conjugated with anti-OX40 antibody; when used in combination with A2-CL/Dbait nanoparticles and radiotherapy, it prolongs survival time and reduces tumor volume in glioblastoma mouse models. MPEG-PLGA (21500-26500) can be used for studies related to bacterial wound infections and glioblastoma^[1]^[2]^[3].
In Vitro	MPEG-PLGA (21500-26500) covalent grafting of MSI-78 (4-20) at a concentration of 326 μg/mL yields a positively charged stable nanosystem. This product exhibits MIC values of 16-32 μg/mL and 8-16 μg/mL against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, respectively. In simulated wound fluid, only its anti-P. aeruginosa activity slightly decreases, while its bactericidal rate is significantly enhanced, and no cytotoxicity to HFF-1 cells is observed at the MIC dose^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. mPEG-PLGA (21500-26500) Related Antibodies
Molecular Weight	Average Mn (21500-26500)
CAS No.	743423-15-6
Appearance	Solid
Color	Off-white to light yellow
SMILES	COCCOC(COC(C(C)O[H])=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility	In Vitro: DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Molarity Calculator Dilution Calculator Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Mass = Concentration × Volume × Molecular Weight * Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final) This equation is commonly abbreviated as: C₁V₁ = C₂V₂ Concentration _(start) C1 × Volume _(start) V1 = Concentration _(final) C2 × Volume _(final) V2 In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kg Animal weight (per animal) g Dosing volume (per animal) μL Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL
Purity & Documentation	Purity: 95.0% Select Batch: Data Sheet (267 KB) SDS (252 KB) COA (245 KB) Handling Instructions (2659 KB)
References	[1]. Que Y, et al. Tetracycline-grafted mPEG-PLGA micelles for bone-targeting and osteoporotic improvement. Front Pharmacol. 2022;13:993095. Published 2022 Sep 14. [Content Brief]