USP14

Isoforms Recommended:	USP14

By Targets:	Apoptosis (3) Autophagy (2) Bcr-Abl (1) ByeTAC (1) Deubiquitinase (8) Epigenetic Reader Domain (1) HDAC (1) Parasite (1) PARP (1) PROTACs (1) Proteasome (2) Proteasome Cap Targeting Chimeras (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Endocrinology (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13817

IU1 Maximum Cited Publications 25 Publications Verification	Deubiquitinase Autophagy Apoptosis	Cardiovascular Disease Neurological Disease Endocrinology Cancer
IU1 is a selective, reversible *USP14* inhibitor with an IC₅₀ of 4-5 μM. IU1 binds *USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub* thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .

HY-13264

Degrasyn 15+ Cited Publications WP1130	Deubiquitinase Bcr-Abl Autophagy Apoptosis	Cancer
Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.

HY-13989

b-AP15 10+ Cited Publications NSC 687852	Deubiquitinase Apoptosis	Cancer
b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and *Usp14*.

HY-122243

IU1-47 3 Publications Verification	Deubiquitinase	Neurological Disease
IU1-47 is a potent and specific *USP14* inhibitor with an IC₅₀ of 0.6 μM. IU1-47 inhibits IsoT/USP5 with an IC₅₀ of 20 μM. IU1-47 induces tau elimination in cultured neurons .

HY-122885

IU1-248 1 Publications Verification	Deubiquitinase	Cancer
IU1-248, a derivative of IU1, is a potent and selective *USP14* inhibitor with an IC₅₀ of 0.83 μM.

HY-RS15525

USP14 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
USP14 Human Pre-designed siRNA Set A contains three designed siRNAs for USP14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

USP14 Human Pre-designed siRNA Set A USP14 Human Pre-designed siRNA Set A

HY-RS23069

Usp14 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Usp14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Usp14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Usp14 Rat Pre-designed siRNA Set A Usp14 Rat Pre-designed siRNA Set A

HY-RS16634

Usp14 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Usp14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Usp14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Usp14 Mouse Pre-designed siRNA Set A Usp14 Mouse Pre-designed siRNA Set A

HY-176207

HDAC degrader-1	ByeTAC HDAC	Cancer
HDAC6 degrader-6 (compound 10c) is a ByeTAC protein degrader targeting HDAC6, with IC₅₀ values of 0.034 μM, 0.166 μM, 0.703 μM, and 0.293 μM for HDAC6, HDAC1, HDAC2, and HDAC3, respectively. HDAC6 degrader-6 induces cell apoptosis and can be used for the study of multiple myeloma(Blue: USP14 ligand HY-159808; Pink: HDAC ligand HY-176209; Black: linker HY-W016871)

HY-15432

(E/Z)-NSC-687852 (E/Z)-b-AP15	Deubiquitinase	Cancer
(E/Z)-NSC-687852 is a isomer of NSC-687852 (HY-13989). NSC687852 (b-AP15) is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14 .

HY-135779

IU2-6	Deubiquitinase	Neurological Disease
IU2-6 is a *USP14* deubiquitinase inhibitor. IU2-6 inhibits deubiquitinating activity of proteasome-associated USP14, blocks substrate rescue from degradation, and enhances proteasomal activity. IU2-6 can be used for the research of neurodegeneration .

HY-164689

Cadmium pyrithione	Proteasome	Cancer
Cadmium pyrithione is a metal compound that inhibits protein deubiquitinase activity. Cadmium pyrithione treatment results in significant accumulation of ubiquitinated proteins in cancer cells and primary leukemia cells. Cadmium pyrithione strongly inhibits the activity of proteasome deubiquitinase (such as USP14 and UCHL5), but has a smaller inhibitory effect on 20S proteasome activity. The anticancer activity of Cadmium pyrithione is associated with the induction of apoptosis through caspase activation. Furthermore, Cadmium pyrithione inhibition inhibited proteasome function and suppressed tumor growth in animal xenograft models .

HY-D1236

Fluorescent brightener 71	Parasite Deubiquitinase PARP	Cancer
Fluorescent brightener 71 (FB71) is an inhibitor targeting deubiquitinases UCHL5 and *USP14, as well as a CD40* ligand. Fluorescent brightener 71 blocks enzymatic activity, induces apoptosis, inhibits cell growth and triggers reactive oxygen species production. Meanwhile, Fluorescent brightener 71 upregulates the expression of oxidative stress-related genes *gpx-4* and *sod-4, and reversibly increases the protein levels of UCHL5 and USP14* through a feedback response. Fluorescent brightener 71 inhibits the growth, movement and reproductive capacity of Caenorhabditis elegans, and also exhibits concentration-dependent toxic effects. Fluorescent brightener 71 can be applied to scientific research in related fields such as breast cancer .

HY-181495

RAJQ14	Proteasome Cap Targeting Chimeras PROTACs Proteasome Epigenetic Reader Domain	Cancer
RAJQ14 is a BRD4 PROTAC-like CAP-TAC (Proteasome Cap Targeting Chimeras) degrader. RAJQ14 binds to 19S proteasome cap subunits RPN1, RPN10, RPN13, and USP14 to recruit target proteins to the proteasome for ubiquitination-independent, proteasome-dependent degradation. RAJQ14 can be used for the research of cancer (Pink: BRD4 Ligand (HY-181496); Blue: Proteasome Ligand (HY-128978); Black: Linker).

Cat. No.	Product Name	Type

HY-D1236

Fluorescent brightener 71	Fluorescent Dyes
Fluorescent brightener 71 (FB71) is an inhibitor targeting deubiquitinases UCHL5 and *USP14, as well as a CD40* ligand. Fluorescent brightener 71 blocks enzymatic activity, induces apoptosis, inhibits cell growth and triggers reactive oxygen species production. Meanwhile, Fluorescent brightener 71 upregulates the expression of oxidative stress-related genes *gpx-4* and *sod-4, and reversibly increases the protein levels of UCHL5 and USP14* through a feedback response. Fluorescent brightener 71 inhibits the growth, movement and reproductive capacity of Caenorhabditis elegans, and also exhibits concentration-dependent toxic effects. Fluorescent brightener 71 can be applied to scientific research in related fields such as breast cancer .

Fluorescent brightener 71

Fluorescent Dyes

Fluorescent brightener 71 (FB71) is an inhibitor targeting deubiquitinases UCHL5 and USP14, as well as a CD40 ligand. Fluorescent brightener 71 blocks enzymatic activity, induces apoptosis, inhibits cell growth and triggers reactive oxygen species production. Meanwhile, Fluorescent brightener 71 upregulates the expression of oxidative stress-related genes gpx-4 and sod-4, and reversibly increases the protein levels of UCHL5 and USP14 through a feedback response. Fluorescent brightener 71 inhibits the growth, movement and reproductive capacity of Caenorhabditis elegans, and also exhibits concentration-dependent toxic effects. Fluorescent brightener 71 can be applied to scientific research in related fields such as breast cancer .

Species:	Human (2)
Tag:	His (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703671

	USP14 Protein, Human Ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14; USP14; TGT	Human	E. coli
	USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. USP14 Protein, Human is the recombinant human-derived USP14 protein, expressed by E. coli, with tag free.

HY-P71418

	USP14 Protein, Human (His) 1 Publications Verification Ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14; Ubiquitin Thioesterase 14; Ubiquitin-Specific-Processing Protease 14; USP14; TGT	Human	E. coli
	USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. USP14 Protein, Human (His) is the recombinant human-derived USP14 protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Mouse (1) Rabbit (1)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	ICC/IF (1) WB (2) FC (1)
Isotype:	IgG (1) IgG1 (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87565

	USP14 Antibody (YA7249)	WB	Human, Mouse, Rat
	USP14 Antibody (YA7249) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to USP14.

HY-P83583

	PMS2 Antibody (YA3328) TGT; tRNA guanine transglycosylase 60 kD subunit; Ubiquitin carboxyl terminal hydrolase 14; Ubiquitin specific peptidase 14; USP14	WB, ICC/IF, FC	Human, Mouse, Rat
	PMS2 Antibody (YA3328) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PMS2.

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Cat. No.	Product Name		Classification

HY-RS15525

USP14 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
USP14 Human Pre-designed siRNA Set A contains three designed siRNAs for USP14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23069

Usp14 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Usp14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Usp14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16634

Usp14 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Usp14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Usp14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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