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Results for "

USP28

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

2

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149230
    USP28-IN-4

    		Deubiquitinase Cancer
    USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .
    USP28-IN-4
  • HY-138698
    FT206
    1 Publications Verification

    		 Deubiquitinase Cancer
    FT206 is the inhibitor for ubiquitin-specific protease that inhibits USP28 and USP25 with IC50s of 0.15 μM and 1.01 μM .
    FT206
  • HY-153996
    CT1113

    		Deubiquitinase Apoptosis Bcr-Abl STAT c-Myc Cancer
    CT1113 is a selective, orally active USP25/USP28 inhibitor. CT1113 inhibits cancer cell proliferation, induces apoptosis, and causes G2/S phase cell cycle arrest. CT1113 reduces the levels of total BCR-ABL1, phosphorylated BCR-ABL1, total STAT5, and phosphorylated STAT5, but does not alter the mRNA level of BCR-ABL1. CT1113 is applicable to research related to pancreatic cancer, colon cancer, and acute leukemia .
    CT1113
  • HY-149229
    USP28-IN-3

    		Deubiquitinase Cancer
    USP28-IN-3 is a USP28 inhibitor (IC50=0.1 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-3 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-3 also decreases the ankyrase-1/2 level in vitro. USP28-IN-3 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .
    USP28-IN-3
  • HY-149228
    USP28-IN-2

    		Deubiquitinase Cancer
    USP28-IN-2 is a USP28 inhibitor (IC50=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-2 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-2 also decreases the ankyrase-1/2 level in vitro. USP28-IN-2 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .
    USP28-IN-2
  • HY-RS15538
    USP28 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    USP28 Human Pre-designed siRNA Set A contains three designed siRNAs for USP28 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    USP28 Human Pre-designed siRNA Set A
    USP28 Human Pre-designed siRNA Set A
  • HY-RS24473
    Usp28 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Usp28 Rat Pre-designed siRNA Set A contains three designed siRNAs for Usp28 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Usp28 Rat Pre-designed siRNA Set A
    Usp28 Rat Pre-designed siRNA Set A
  • HY-RS18001
    Usp28 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Usp28 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Usp28 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Usp28 Mouse Pre-designed siRNA Set A
    Usp28 Mouse Pre-designed siRNA Set A
  • HY-122686
    USP25/28-IN-2

    		Deubiquitinase Cancer
    USP25/28-IN-2 (compound AZ2) is a selectivity dual USP25/USP28 inhibitor with USP28 IC50 values of 0.9 μM, USP28 Ka values of 0.9 μM, and USP25 IC50 values of 0.88 μM. USP25/28-IN-2 modulates USP25 and USP28 activity to affect downstream pathways, modulates c-Myc oncoprotein total levels and half-life, induces apoptosis, reduces cell viability. USP25/28-IN-2 can be used for the research of colorectal carcinoma, colorectal adenocarcinoma .
    USP25/28-IN-2
  • HY-182681
    AV-9606-129

    		Deubiquitinase c-Myc Cancer
    AV-9606-129 is a USP28 inhibitor with an IC50 of < 1 μM. AV-9606-129 inhibits the enzymatic activity of USP28 and downregulates the protein levels of c-Myc and c-Myb. AV-9606-129 can be used in cancer research .
    AV-9606-129
  • HY-183604
    T-10531

    		Deubiquitinase Cancer
    T-10531 is a selective USP25/USP28 inhibitor. T-10531 exhibits an IC50 of 0.03 μM and a Kd of 0.2 μM against human USP25, as well as an IC50 of 0.12 μM and a Kd of 0.06 μM against human USP28. T-10531 inhibits USP25/USP28 activity and induces the degradation of USP25 via the proteasomal pathway, without inhibiting other deubiquitinases. T-10531 can be used in the research of squamous cell carcinoma, colorectal cancer, gastric cancer, triple-negative breast cancer and pancreatic cancer .
    T-10531

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