3129176-25-3
Chemical Structure
T-10531
- CAS No.: 3129176-25-3
- Formula:C26H22BrClF4N2O5S
- Molecular Weight:665.88
InChIKey: CJJKUHCLJPVDIG-AWEZNQCLSA-N
SMILES: O=C(NC1=CC(F)=C(F)C(COC2=CC(F)=C(Br)C=C2CN3C[C@@H](O)CC3)=C1F)C4=CC=C(S(=O)(C)=O)C=C4Cl
Biological Activity: T-10531 is a selective USP25/USP28 inhibitor. T-10531 exhibits an IC50 of 0.03 μM and a Kd of 0.2 μM against human USP25, as well as an IC50 of 0.12 μM and a Kd of 0.06 μM against human USP28. T-10531 inhibits USP25/USP28 activity and induces the degradation of USP25 via the proteasomal pathway, without inhibiting other deubiquitinases. T-10531 can be used in the research of squamous cell carcinoma, colorectal cancer, gastric cancer, triple-negative breast cancer and pancreatic cancer[1].
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T-10531 | T-10531 is a selective USP25/USP28 inhibitor. T-10531 exhibits an IC50 of 0.03 μM and a Kd of 0.2 μM against human USP25, as well as an IC50 of 0.12 μM and a Kd of 0.06 μM against human USP28. T-10531 inhibits USP25/USP28 activity and induces the degradation of USP25 via the proteasomal pathway, without inhibiting other deubiquitinases. T-10531 can be used in the research of squamous cell carcinoma, colorectal cancer, gastric cancer, triple-negative breast cancer and pancreatic cancer. | |||||||||||||||||||||
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