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VARS1-IN-1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Nom du produit Target Áreas de investigación Chemical Structure
  • HY-180995
    VARS1-IN-1

    		DNA/RNA Synthesis Cancer
    VARS1-IN-1 is a valyl-tRNA synthetase (VARS1) inhibitor with a Kd of 0.213 μM. VARS1-IN-1 suppresses VARS1’s tRNA aminoacylation activity, reduces charged levels of valine tRNAs and redues total protein synthesis rate. VARS1-IN-1 suppresses aggressive tumor growth and cell proliferation in PC3 prostate cancer xenograft models. VARS1-IN-1 can be used for the research of prostate cancer .
    VARS1-IN-1
  • HY-180996
    VARS1-IN-2

    		Aminoacyl-tRNA Synthetase Cancer
    VARS1-IN-2 (Compound 2901) is a VARS1 inhibitor with a Kd of 0.014 µM. VARS1-IN-2 does not alter VARS1 expression either at mRNA or protein level. VARS1-IN-2 exerts anti-prostate cancer effects mainly through interfering VARS1’s tRNA aminoacylation activity but not its expression .
    VARS1-IN-2

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