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Cat. No.: HY-180995

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VARS1-IN-1

VARS1-IN-1 is a valyl-tRNA synthetase (VARS1) inhibitor with a K_d of 0.213 μM. VARS1-IN-1 suppresses VARS1’s tRNA aminoacylation activity, reduces charged levels of valine tRNAs and redues total protein synthesis rate. VARS1-IN-1 suppresses aggressive tumor growth and cell proliferation in PC3 prostate cancer xenograft models. VARS1-IN-1 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 428830-84-6
Formula: C₂₁H₁₅N₅OS
Molecular Weight:385.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

VARS1-IN-1 Chemical Structure

CAS No.: 428830-84-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

VARS1-IN-1 (Compound 2701) (10 µM; 2 days) interfers VARS1’s tRNA aminoacylation activity but not its expression with a reduction in charged to total tRNA-Val ratio in prostate cancer cells^[1].
VARS1-IN-1 (10 µM; 2 days) redues total protein synthesis rate in PC3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VARS1-IN-1 (Compound 2701) (15 mg/kg; i.p.; once every other day for 20 days) suppresses tumor growth and cell proliferation in male BALB/c-nu nude mice PC3 prostate cancer xenograft^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c-nu nude mice with PC3 xenograft (male, 6-7 weeks old)^[1]
Dosage:

15 mg/kg
Administration:

i.p.; once every other day for 20 days
Result:

Inhibited tumor growth with significant reduction in tumor weight compared to DMSO control.
Decreased cell proliferation index as shown by Ki-67 immunohistochemical staining.

Chemical Information

CAS No. 428830-84-6
Molecular Weight 385.44
Formula C₂₁H₁₅N₅OS
SMILES

CC1=CC=C(C2=NN(C(/C3=C/C4=CNC5=C4C=CC=C5)=N)C(S2)=NC3=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He Q, et al. VARS1 fuels prostate cancer evolution via codon-selective translational rewiring[J]. bioRxiv, 2025: 2025.12. 09.693333.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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