2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. VARS1-IN-1

VARS1-IN-1 is a valyl-tRNA synthetase (VARS1) inhibitor with a Kd of 0.213 μM. VARS1-IN-1 suppresses VARS1’s tRNA aminoacylation activity, reduces charged levels of valine tRNAs and redues total protein synthesis rate. VARS1-IN-1 suppresses aggressive tumor growth and cell proliferation in PC3 prostate cancer xenograft models. VARS1-IN-1 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

VARS1-IN-1

VARS1-IN-1 Chemical Structure

CAS No. : 428830-84-6

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VARS1-IN-1 Related Antibodies

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Description

VARS1-IN-1 is a valyl-tRNA synthetase (VARS1) inhibitor with a Kd of 0.213 μM. VARS1-IN-1 suppresses VARS1’s tRNA aminoacylation activity, reduces charged levels of valine tRNAs and redues total protein synthesis rate. VARS1-IN-1 suppresses aggressive tumor growth and cell proliferation in PC3 prostate cancer xenograft models. VARS1-IN-1 can be used for the research of prostate cancer[1].

In Vitro

VARS1-IN-1 (Compound 2701) (10 µM; 2 days) interfers VARS1’s tRNA aminoacylation activity but not its expression with a reduction in charged to total tRNA-Val ratio in prostate cancer cells[1].
VARS1-IN-1 (10 µM; 2 days) redues total protein synthesis rate in PC3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VARS1-IN-1 Related Antibodies
In Vivo

VARS1-IN-1 (Compound 2701) (15 mg/kg; i.p.; once every other day for 20 days) suppresses tumor growth and cell proliferation in male BALB/c-nu nude mice PC3 prostate cancer xenograft[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c-nu nude mice with PC3 xenograft (male, 6-7 weeks old)[1]
Dosage: 15 mg/kg
Administration: i.p.; once every other day for 20 days
Result: Inhibited tumor growth with significant reduction in tumor weight compared to DMSO control.
Decreased cell proliferation index as shown by Ki-67 immunohistochemical staining.
Molecular Weight

385.44

Formula

C21H15N5OS
CAS No.
SMILES

CC1=CC=C(C2=NN(C(/C3=C/C4=CNC5=C4C=CC=C5)=N)C(S2)=NC3=O)C=C1
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Purity & Documentation
References
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VARS1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VARS1-IN-1428830-84-6DNA/RNA Synthesisprostate cancervaline tRNAvaline tRNAsPC3Inhibitorinhibitorinhibit

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