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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
VP1
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "VP1" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N0620
CAS No.: 102841-43-0
Cat. No.: HY-W019806
CAS No.: 7578-25-8
Synonyms: LNFP I
Cat. No.: HY-131686
CAS No.: 59247-13-1
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Ganglioside GT1b (bovine) ammonium is a member of the ganglioside family. Ganglioside GT1b (bovine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (bovine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (bovine) ammonium enhances porcine oocyte maturation and induce activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (bovine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (bovine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease [1] .
Cat. No.: HY-111233
CAS No.: 87495-31-6
Synonyms: WIN-51711
Target:
Research Areas:
Disoxaril (WIN-51711) is an antivirus agent with activity against poliovirus types 1 and 2. Disoxaril inserts into the hydrophobic interior of virus capsid protein VP1 to stabilize virion conformation, inhibits poliovirus uncoating, and prevents viral RNA release and synthesis. Disoxaril can be used for the research of poliovirus infection [1] .
Cat. No.: HY-183010
CAS No.: 173900-00-0
Research Areas:
VP1 ligand-1 (Scheme 1 A 1) is a VP1 ligand. VP1 ligand-1 acts as a ligand for target protein for PROTAC (Ligands for Target Protein for PROTAC) and is used for the development and design of PROTAC-based VP1 degraders, such as Jun15702 (HY-182924). VP1 ligand-1 is applicable to EV-D68 infection research [1].
Cat. No.: HY-183014
Research Areas:
VP1 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used for the synthesis of PROTACs, such as Jun15702 (HY-182924) [1].
Cat. No.: HY-145850
CAS No.: 2413648-96-9
Target:
Research Areas:
EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an EC50 of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC50>56.2 μM) [1].
Cat. No.: HY-P991153
CAS No.: 2923558-06-7
Target:
Research Areas:
Cat. No.: HY-P72307
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Major structural protein VP1
Species:
Source:
Cat. No.: HY-P75251
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Enterovirus D68 (EV-D68) (strain Fermon) VP1 Protein
Species:
Source:
Cat. No.: HY-182924
Target:
Research Areas:
Jun15702 is a PROTAC degrader targeting the capsid protein VP1 of enterovirus D68. Jun15702 recruits the Cereblon (CRBN) E3 ligase and activates the ubiquitin-proteasome pathway. Jun15702 inhibits viral entry and exerts inhibitory effects during the early, middle and late stages of viral replication. Jun15702 exhibits antiviral activity against multiple wild-type enterovirus D68 strains, and also shows submicromolar antiviral activity against the Pleconaril (HY-19952)-resistant enterovirus D68 variant rMO-VP1 F159V. Jun15702 can be used in studies related to enterovirus D68 (EV-D68) infection [1].
Cat. No.: HY-183011
CAS No.: 2953426-96-3
Target:
Research Areas:
CRBN ligand-901 (5d in Scheme 2) is a ligand for Cereblon (CRBN). CRBN ligand-901 can be linked to target protein ligands (e.g., VP1 ligand-1) via a linker to form PROTAC molecules (e.g., Jun15702 (HY-182924)) [1].
Cat. No.: HY-P76280
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein; VP1 Protein; CV
Species:
Source:
Cat. No.: HY-178835
CAS No.: 314768-41-7
Target:
Research Areas:
R523062 is a viral 2C inhibitor. R523062 reduces the viral VP1 protein. R523062 displays a broad-range antiviral activity against EV-D68 strains [1].
Cat. No.: HY-N16775
CAS No.: 206876-12-2
Target:
Target:
Research Areas:
H1PVAT is a potent and selective inhibitor of poliovirus serotypes (PV-1, PV-2, PV-3), and inhibits early stage of the replication. H1PVAT interacts with viral capsid directly and protects PV against heat inactivation [1] .
Cat. No.: HY-153517
CAS No.: 2104030-01-3
Target:
Research Areas:
hRVs-IN-1 (Compound 6g) is a selective anti-hRV viral agent. hRVs-IN-1 inhibits the replication of tested hRV strains with EC50 values of 0.083, 0.078, and 0.015 μM against hRV-B14, hRV-A21, and hRV-A71, respectively. hRVs-IN-1 inhibits the replication of PV3 with an EC50 of 0.063 μM [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
