59247-13-1
Chemical Structure
Ganglioside GT1b (bovine) ammonium
- CAS No.: 59247-13-1
- Formula:N/A
- Molecular Weight:N/A
SMILES: O[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC[Ceramide])CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O[C@]5(C(O)=O)C[C@@H]([C@H]([C@@H](O5)[C@H](O)[C@H](O)CO)NC(C)=O)O)O)O)CO)O[C@]6(C(O)=O)C[C@@H]([C@H]([C@@H](O6)[C@H](O)[C@H](O[C@]7(C(O)=O)C[C@@H]([C@H]([C@@H](O7)[C@H](O)[C@H](O)CO)NC(C)=O)O)CO)NC(C)=O)O)O)O.N.N.N
Biological Activity: Ganglioside GT1b (bovine) ammonium is a member of the ganglioside family. Ganglioside GT1b (bovine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (bovine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (bovine) ammonium enhances porcine oocyte maturation and induce activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (bovine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (bovine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ganglioside GT1b (bovine) ammonium | 98% | Ganglioside GT1b (bovine) ammonium is a member of the ganglioside family. Ganglioside GT1b (bovine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (bovine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (bovine) ammonium enhances porcine oocyte maturation and induce activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (bovine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (bovine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease. | ||||||||||||||||||||
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Ganglioside GT1b (porcine) ammonium | 98% | Ganglioside GT1b (porcine) ammonium is a member of the ganglioside family. Ganglioside GT1b (porcine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (porcine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (porcine) ammonium enhances porcine oocyte maturation and induces activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (porcine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (porcine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease. | ||||||||||||||||||||
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- [1]. Yoo HK, et al. Ganglioside GT1b increases hyaluronic acid synthase 2 via PI3K activation with TLR2 dependence in orbital fibroblasts from thyroid eye disease patients. BMB Rep. 2021;54(2):136-141. [Content Brief]
- [2]. Hwang SU, et al. Effect of ganglioside GT1b on the in vitro maturation of porcine oocytes and embryonic development. J Reprod Dev. 2015;61(6):549-557. [Content Brief]
- [3]. Katoh N. Inhibition by gangliosides GM3, GD3 and GT1b of substrate phosphorylation by protein kinase C in bovine mammary gland and its reversal by phosphatidylserine. Life Sci. 1995;56(3):157-62. [Content Brief]
- [4]. Lee J, et al. Ganglioside GT1b prevents selective spinal synapse removal following peripheral nerve injury. EMBO Rep. 2025;26(12):2994-3023. [Content Brief]
- [5]. Kim JW, et al. Exogenous Ganglioside GT1b Enhances Porcine Oocyte Maturation, Including the Cumulus Cell Expansion and Activation of EGFR and ERK1/2 Signaling. Reprod Sci. 2020;27(1):278-289. [Content Brief]
- [6]. Erickson KD, et al. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. J Virol. 2009;83(19):10275-10279. [Content Brief]
