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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
Waf1/Cip1
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "Waf1/Cip1" in MCE Product Catalog:
6
6 Publications Verification
Synonyms: Purapuridine; Solancarpidine; Solasodin
Category:
Cardiovascular Disease Neurological Disease Plants Infection Alkaloids Piperidine Alkaloids Solanum nigrum Linn. Solanaceae Disease Research Fields Inflammation/Immunology
Target:
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1 Cited Publications
Cat. No.: HY-P704204
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CDKN1A; Cdk-Interacting Protein 1; Prev. CDKN1; MDA-6; CAP20; Melanoma Differentiation Associated Protein 6; Cip1; Melanoma Differentiation-Associated Protein 6; Waf1; Wild-Type P53-Activated Fragment 1; SDI1; CDK-Interaction Protein 1; P21; CDK-Interacti
Cat. No.: HY-16138
CAS No.: 936221-33-9
Synonyms: CG-200745
Ivaltinostat (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat inhibits deacetylation of histone H3 and tubulin. Ivaltinostat induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat induces apoptosis and has anti-tumour effects [1] .
Cat. No.: HY-16138A
CAS No.: 3078712-42-9
Synonyms: CG-200745 formic
Research Areas:
Ivaltinostat (CG-200745) formic is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat formic enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat formic induces apoptosis and has anti-tumour effects [1] .
Synonyms: R306465
JNJ-16241199 (R306465) is an orally active, selectivehydroxamate-based histone deacetylase (HDAC) inhibitor, with theIC50of 3.3 nM and 23 nM for HDAC1and HDAC8, respectively.JNJ-16241199induces histone 3 acetylation and strongly increases
the expression of p21 waf1, cip1 in A2780 ovarian carcinoma cells.JNJ-16241199 inducescell apoptosisand shows anticancer activityin a broad spectrum of human malignancies. JNJ-16241199 can be used for cancer study [1].
Cat. No.: HY-18343
CAS No.: 259199-65-0
CP-31398 can stabilize the active conformation of p53 and promote p53 activity in cancer cells with either mutant or wild-type p53. In addition, CP-31398 can upregulate p53 target genes, such as p21WAF1/Cip1 and KILLER/DR5. CP-31398 exerts an inhibitory effect on tumor growth [1] .
Synonyms: (Z)-3,5,4'-Trimethoxystilbene
Target:
Research Areas:
cis-Trismethoxy resveratrol ((Z)-3,5,4'-Trimethoxystilbene) is an anti-HCV agent and Tubulin inhibitor, with an IC50 of 4 μM against Tubulin. cis-Trismethoxy resveratrol induces G2/M phase cell cycle arrest, reduces DCLK1, decreases CDK1 levels, blocks phosphorylation of Akt Ser 473, and induces the expression of p21 Cip1/Waf1. cis-Trismethoxy resveratrol exhibits anti-tumor and hepatoprotective activities. cis-Trismethoxy resveratrol can be used in studies related to colon adenocarcinoma, hepatocellular carcinoma, hepatitis C, and liver injury [1] .
Cat. No.: HY-N13944
CAS No.: 444300-74-7
Category:
Target:
Cat. No.: HY-W751400
CAS No.: 6106-33-8
Synonyms: Purapuridine hydrochloride; Solancarpidine hydrochloride; Solasodin hydrochloride
Target:
Research Areas:
Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities [1] .
Cat. No.: HY-N11852
CAS No.: 51415-08-8
Category:
Target:
Cat. No.: HY-P10914
CAS No.: 1426227-11-3
Research Areas:
Cat. No.: HY-P80773A
Synonyms: CDKN1A; CAP20; CDKN1; Cip1; MDA6; PIC1; SDI1; Waf1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21
Cat. No.: HY-P700570
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDKN1A; Cdk-Interacting Protein 1; Prev. CDKN1; MDA-6; CAP20; Melanoma Differentiation Associated Protein 6; Cip1; Melanoma Differentiation-Associated Protein 6; Waf1; Wild-Type P53-Activated Fragment 1; SDI1; CDK-Interaction Protein 1; P21; CDK-Interacti
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
