94608-23-8
Chemical Structure
cis-Trismethoxy resveratrol
Synonym(s): (Z)-3,5,4'-Trimethoxystilbene
- CAS No.: 94608-23-8
- Formula:C17H18O3
- Molecular Weight:270.32
IUPAC Name: (Z)-1,3-dimethoxy-5-(4-methoxystyryl)benzene
InChIKey: GDHNBPHYVRHYCC-PLNGDYQASA-N
SMILES: COC1=CC(/C=C\C2=CC=C(C=C2)OC)=CC(OC)=C1
Biological Activity: cis-Trismethoxy resveratrol ((Z)-3,5,4'-Trimethoxystilbene) is an anti-HCV agent and Tubulin inhibitor, with an IC50 of 4 μM against Tubulin. cis-Trismethoxy resveratrol induces G2/M phase cell cycle arrest, reduces DCLK1, decreases CDK1 levels, blocks phosphorylation of Akt Ser473, and induces the expression of p21Cip1/Waf1. cis-Trismethoxy resveratrol exhibits anti-tumor and hepatoprotective activities. cis-Trismethoxy resveratrol can be used in studies related to colon adenocarcinoma, hepatocellular carcinoma, hepatitis C, and liver injury[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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cis-Trismethoxy resveratrol | 99.87% | cis-Trismethoxy resveratrol ((Z)-3,5,4'-Trimethoxystilbene) is an anti-HCV agent and Tubulin inhibitor, with an IC50 of 4 μM against Tubulin. cis-Trismethoxy resveratrol induces G2/M phase cell cycle arrest, reduces DCLK1, decreases CDK1 levels, blocks phosphorylation of Akt Ser473, and induces the expression of p21Cip1/Waf1. cis-Trismethoxy resveratrol exhibits anti-tumor and hepatoprotective activities. cis-Trismethoxy resveratrol can be used in studies related to colon adenocarcinoma, hepatocellular carcinoma, hepatitis C, and liver injury. | ||||||||||||||||||||
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- [1]. Schneider Y, et al. Resveratrol analog (Z)-3,5,4'-trimethoxystilbene is a potent anti-mitotic drug inhibiting tubulin polymerization. Int J Cancer. 2003;107(2):189-196. [Content Brief]
- [2]. Nguyen CB, et al. (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression. Cancer Res. 2016;76(16):4887-4896. [Content Brief]
Keywords
