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alkaloid derivative

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (8) Adenosine Receptor (1) Bacterial (2) Biochemical Assay Reagents (3) Cholinesterase (ChE) (1) Drug Intermediate (1) Endogenous Metabolite (1) IKK (3) Isotope-Labeled Compounds (2) Microtubule/Tubulin (1) MMP (1) NF-κB (1) p38 MAPK (1) Phosphodiesterase (PDE) (3) Reference Standards (2) Sodium Channel (3) Topoisomerase (2)
By Research Areas:	Cancer (10) Cardiovascular Disease (4) Infection (4) Inflammation/Immunology (8) Metabolic Disease (2) Neurological Disease (8)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Derivative

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincaminate	Sodium Channel IKK Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-139570

Ecubectedin PM14	Bacterial	Infection Inflammation/Immunology Cancer
Ecubectedin (PM14) is a derivative. Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities .

HY-W014971

Tryptamine hydrochloride 1 Publications Verification	Biochemical Assay Reagents	Others
Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

HY-W001963

Pyrrole-2-carboxylic acid	Endogenous Metabolite	Others
Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov. Pyrrole-2-carboxylic acid is a biological form of pyrrole that is often encountered in natural compounds. Pyrrole-2-carboxylic acid serves as a precursor for various pyrrole derivatives like clorobiocin, coumermycin A1, pyoluteorin, leupyrrins, and undecylprodigiosin in biosynthetic processes .

HY-118581

Coralyne chloride 1 Publications Verification	Topoisomerase	Cancer
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes .

HY-W178327

8-Chloro caffeine	Adenosine Receptor	Cancer
8-Chloro caffeine binds to adenosine receptors (K_i = 30 µM). 8-Chloro caffeine potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine .

HY-A0220

Rescinnamine 1 Publications Verification Reserpinine	Drug Derivative	Cardiovascular Disease Metabolic Disease
Rescinnamine is a derivative of the indole alkaloid reserpine. Rescinnamine shows sedative effects. Rescinnamine can be used for hypertension research .

HY-N4012

Indole-3-glyoxylamide 3-Indoleglyoxamide	Others	Others
Indole-3-glyoxylamide (Compound 4) is a type of indole alkaloid. Indole-3-glyoxylamide shows no significant cytotoxic activity against Hela, Ishikawa, and MGC-803 cells .

HY-13295R

Vinpocetine (Standard) Ethyl apovincaminate (Standard)	Reference Standards Sodium Channel IKK Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Vinpocetine (Standard) is the analytical standard of Vinpocetine. This product is intended for research and analytical applications. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N12726

Halociline	p38 MAPK MMP	Infection Inflammation/Immunology Cancer
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities .

HY-118425

(+)-Adlumine O-Methylcorledine	Drug Derivative	Others
(+)-Adlumine (O-Methylcorledine) is an alkaloid derivative found in Corydalis ledebouriana .

HY-W033010

Pseudotropine β-Tropine	Drug Derivative	Others
Pseudotropine (β-Tropine), a derivative of Tropane, is a plant alkaloid .

HY-W665464

(Rac)-7-Ethyl-10-hydroxycamptothecin	Drug Derivative Topoisomerase	Cancer
(Rac)-7-Ethyl-10-hydroxycamptothecin is the derivative of (±)-10-Hydroxycamptothecin (HY-N0275). (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity .

HY-172530

Heptanoyl-coenzyme A tetrasodium	Biochemical Assay Reagents	Neurological Disease
Heptanoyl-coenzyme A (Heptanoyl-CoA) tetrasodium is a derivative of CoA. Heptanoyl-coenzyme A tetrasodium is an inhibitor of butyryl-CoA acetate-CoA transferase (BUT) and inhibits butyric acid synthesis. Heptanoyl-coenzyme A tetrasodium blocks the improvements in motor function induced by the isoquinoline alkaloid Berberine (HY-N0716) .

HY-106072

Vinzolidine LY 104208	Microtubule/Tubulin	Cancer
Vinzolidine is a semisynthetic derivative of the catharanthus alkaloid. Vinzolidine exerts its cytotoxic effect on tumor cells by interfering with microtubulin polymerization, thereby inhibiting cell division. Vinzolidine can be utilized in research to investigate synergistic effects when combined with other chemotherapeutic agents or biologic therapies, as well as to study cancer cells' tolerance or resistance to these treatments, and to explore approaches to overcome such obstacles .

HY-13295S

Vinpocetine-d5	Isotope-Labeled Compounds Sodium Channel IKK Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-105608

Narceine Narcein	Others	Metabolic Disease
Narceine (Narcein), a quinolone derivative, is an opium alkaloid with anti-diabetic property .

HY-172846

6-Methoxy-N,N-diethylpentylone hydrochloride	Drug Derivative	Neurological Disease
6-Methoxy-N,N-diethylpentylone hydrochloride is an alkaloid derivative and can be used for the research of neurological disease.

HY-175065

α-Dimethylaminohexanophenone hydrochloride N,N-Dimethyl hexanophenone hydrochloride; N-Dimethyl hexedrone hydrochloride	Drug Derivative	Neurological Disease
α-Dimethylaminohexanophenone (N,N-dimethyl Hexanophenone, N-dimethyl Hexedrone) hydrochloride is an alkaloid derivative and can be used for the research of neurological disease.

HY-160000

Coumaperine	NF-κB Drug Intermediate	Infection Inflammation/Immunology Cancer
Coumaperine is an amide alkaloid. Coumaperine can be extracted from white piper. Coumaperine inhibits NF-κB. Coumaperine derivatives exhibit anticancer activity against non-small cell lung cancer and Hodgkin's lymphoma. Coumaperine derivatives have antibacterial activity .

HY-W033010R

Pseudotropine (Standard) β-Tropine (Standard)	Drug Derivative Reference Standards	Others
Pseudotropine (Standard) is the analytical standard of Pseudotropine (HY-W033010). This product is intended for research and analytical applications. Pseudotropine (β-Tropine), a derivative of Tropane, is a plant alkaloid .

HY-N18765

Dragons blood extract	Bacterial	Infection Inflammation/Immunology
Dragons blood extract contains a variety of bioactive compounds, including alkaloids, flavonoids, phenolic acids, and chalcone derivatives, which have antibacterial, anti-inflammatory, antioxidant, and wound-healing effects.

HY-N18059

Spiradine A 6-Hydroxyhetisan-11-one	Others	Neurological Disease Inflammation/Immunology
Spiradine A (6-Hydroxyhetisan-11-one) is a C₂₀ diterpenoid alkaloid present in the roots of Thalictrum sessile (Ranunculaceae), and is originally isolated from Spiraea japonica (Rosaceae). Spiradine A may possess anti-inflammatory and analgesic activities .

HY-W014971S

Tryptamine-d2-1 hydrochloride	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
Tryptamine-d₂-1 hydrochloride is the deuterium labeled Tryptamine hydrochloride (HY-W014971). Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

HY-N18289

8-Hydroxydihydrochelerythrine	Cholinesterase (ChE)	Neurological Disease
8-Hydroxydihydrochelerythrine is a benzophenanthridine alkaloid-derived, selective and competitive AChE inhibitor (IC₅₀=0.61 μM) isolated from the roots of Zanthoxylum nitidum (Roxb.) DC. 8-Hydroxydihydrochelerythrine increases the content of acetylcholine in the synapses of cholinergic neurons and enhances cholinergic neurotransmission. 8-Hydroxydihydrochelerythrine is applicable to the research of neurodegenerative diseases with dementia such as Alzheimer's disease .

HY-N9913

11-Hydroxycephalotaxine	Drug Derivative	Others
11-Hydroxycephalotaxine (Compound 1a) is a cephalotaxus alkaloid that can be isolated from Cephalotaxus species .

Cat. No.	Product Name

HY-L021M

Natural Product and Natural Product-Like Compound Library	5,019 compounds
From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research. MCE provides a unique collection of 5,019 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

Natural Product and Natural Product-Like Compound Library

5,019 compounds

From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research.

MCE provides a unique collection of 5,019 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

Cat. No.	Product Name	Type

HY-W014971

Tryptamine hydrochloride 1 Publications Verification	Biochemical Assay Reagents
Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

Tryptamine hydrochloride

1 Publications Verification

Biochemical Assay Reagents

Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincaminate	Cardiovascular Disease Neurological Disease Classification of Application Fields Anti-aging Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Apocynaceae Alkaloids Piperidine Alkaloids Disease Research Fields Source Classification Cancer	Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-W001963

Pyrrole-2-carboxylic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Marine natural products Other Diseases Endogenous metabolite Marine microorganism Disease Research Fields Source Classification	Endogenous Metabolite
Pyrrole-2-carboxylic acid is a natural alkaloid from the marine bacterium Pelomonas puraquae sp. Nov. Pyrrole-2-carboxylic acid is a biological form of pyrrole that is often encountered in natural compounds. Pyrrole-2-carboxylic acid serves as a precursor for various pyrrole derivatives like clorobiocin, coumermycin A1, pyoluteorin, leupyrrins, and undecylprodigiosin in biosynthetic processes .

HY-A0220

Rescinnamine 1 Publications Verification Reserpinine	Apocynaceae Alkaloids Piperidine Alkaloids Rauvolfia serpentina other families Classification of Application Fields Other Alkaloids Metabolic Disease Plants Disease Research Fields Indole Alkaloids Source Classification	Drug Derivative
Rescinnamine is a derivative of the indole alkaloid reserpine. Rescinnamine shows sedative effects. Rescinnamine can be used for hypertension research .

HY-N4012

Indole-3-glyoxylamide 3-Indoleglyoxamide	Structural Classification Alkaloids Solanum melongena L. Solanaceae Plants Indole Alkaloids Source Classification	Others
Indole-3-glyoxylamide (Compound 4) is a type of indole alkaloid. Indole-3-glyoxylamide shows no significant cytotoxic activity against Hela, Ishikawa, and MGC-803 cells .

HY-13295R

Vinpocetine (Standard) Ethyl apovincaminate (Standard)	Apocynaceae Alkaloids Piperidine Alkaloids Structural Classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	Reference Standards Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Standard) is the analytical standard of Vinpocetine. This product is intended for research and analytical applications. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N12726

Halociline	Microorganisms Marine natural products Phenols Marine microorganism Source Classification	p38 MAPK MMP
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities .

HY-118425

(+)-Adlumine O-Methylcorledine	Structural Classification Alkaloids Corydalis mucronifera Maxim. Plants Isoquinoline Alkaloids Papaveraceae Source Classification	Drug Derivative
(+)-Adlumine (O-Methylcorledine) is an alkaloid derivative found in Corydalis ledebouriana .

HY-W033010

Pseudotropine β-Tropine	Alkaloids Classification of Application Fields Erythroxylaceae Other Alkaloids Other Diseases Plants Disease Research Fields Erythroxylum coca Lam. Source Classification	Drug Derivative
Pseudotropine (β-Tropine), a derivative of Tropane, is a plant alkaloid .

HY-105608

Narceine Narcein	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Plants Disease Research Fields Papaveraceae Corydalis longipes Source Classification	Others
Narceine (Narcein), a quinolone derivative, is an opium alkaloid with anti-diabetic property .

HY-160000

Coumaperine	Structural Classification Monophenols Phenols Piperaceae Plants Piper nigrum Linn. Source Classification	NF-κB Drug Intermediate
Coumaperine is an amide alkaloid. Coumaperine can be extracted from white piper. Coumaperine inhibits NF-κB. Coumaperine derivatives exhibit anticancer activity against non-small cell lung cancer and Hodgkin's lymphoma. Coumaperine derivatives have antibacterial activity .

HY-W033010R

Pseudotropine (Standard) β-Tropine (Standard)	Alkaloids Structural Classification Erythroxylaceae Other Alkaloids Plants Erythroxylum coca Lam. Source Classification	Drug Derivative Reference Standards
Pseudotropine (Standard) is the analytical standard of Pseudotropine (HY-W033010). This product is intended for research and analytical applications. Pseudotropine (β-Tropine), a derivative of Tropane, is a plant alkaloid .

HY-N18765

Dragons blood extract	Structural Classification Extract	Bacterial
Dragons blood extract contains a variety of bioactive compounds, including alkaloids, flavonoids, phenolic acids, and chalcone derivatives, which have antibacterial, anti-inflammatory, antioxidant, and wound-healing effects.

HY-N18059

Spiradine A 6-Hydroxyhetisan-11-one	Structural Classification Alkaloids Thalictrum javanicum Blume Pyrrole Alkaloids Ranunculaceae Plants Source Classification	Others
Spiradine A (6-Hydroxyhetisan-11-one) is a C₂₀ diterpenoid alkaloid present in the roots of Thalictrum sessile (Ranunculaceae), and is originally isolated from Spiraea japonica (Rosaceae). Spiradine A may possess anti-inflammatory and analgesic activities .

HY-N18289

8-Hydroxydihydrochelerythrine	Structural Classification Alkaloids Other Alkaloids Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Source Classification	Cholinesterase (ChE)
8-Hydroxydihydrochelerythrine is a benzophenanthridine alkaloid-derived, selective and competitive AChE inhibitor (IC₅₀=0.61 μM) isolated from the roots of Zanthoxylum nitidum (Roxb.) DC. 8-Hydroxydihydrochelerythrine increases the content of acetylcholine in the synapses of cholinergic neurons and enhances cholinergic neurotransmission. 8-Hydroxydihydrochelerythrine is applicable to the research of neurodegenerative diseases with dementia such as Alzheimer's disease .

HY-N9913

11-Hydroxycephalotaxine	Structural Classification Alkaloids Other Alkaloids Cephalotaxus harringtonia Plants Cephalotaxaceae Source Classification	Drug Derivative
11-Hydroxycephalotaxine (Compound 1a) is a cephalotaxus alkaloid that can be isolated from Cephalotaxus species .

Cat. No.	Product Name	Chemical Structure

HY-13295S

Vinpocetine-d5

Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-W014971S

Tryptamine-d2-1 hydrochloride

Tryptamine-d₂-1 hydrochloride is the deuterium labeled Tryptamine hydrochloride (HY-W014971). Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.

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alkaloid derivative

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products