2977255-36-8
2977255-36-8
Chemical Structure
Halociline
- CAS No.: 2977255-36-8
- Formula:C11H17NO2
- Molecular Weight:195.26
InChIKey: AJWRCLREFMYSBJ-UHFFFAOYSA-N
SMILES: CC1=C(C=C(C=C1C(C(O)C)C)O)N
Biological Activity:
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum.
Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities[1][2].
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Halociline | Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum.
Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities. |
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References
- [1]. Mohamed M M Abdel Razek, et al. A New Phenolic Alkaloid from Halocnemum strobilaceum Endophytes: Antimicrobial, Antioxidant and Biofilm Inhibitory Activities. Chem Biodivers. 2020 Oct;17(10):e2000496. [Content Brief]
- [2]. Xiangru Zha, et al. Network pharmacology, molecular docking, and molecular dynamics simulation analysis reveal the molecular mechanism of halociline against gastric cancer. Mol Divers. 2024 Mar 19. [Content Brief]
Keywords
